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Increased serum folate levels associated with reduced breast cancer risk.
2004 AUG 5 - (NewsRx.com & NewsRx.net) -- Increased serum folate levels are associated with reduced breast cancer risk.
"Breast cancer risk may be associated with folate status or the C677T genotype of the methylenetetrahydrofolate reductase (MTHFR) gene. We compared serum folate concentrations and C677T genotype in 141 breast cancer patients and 109 age-matched controls," scientists in Australia report.
"Serum folate was significantly lower in cases compared to controls (geometric means, 5.7 vs. 6.6 mcg/L; p=.005). Breast cancer risk was not associated with C677T genotype," wrote J. Beilby and coauthors.
"After adjusting for age of menarche, parity, alcohol intake and total fat intake," said investigators, "we observed reductions in odds ratios for breast cancer risk comparing the highest with the lowest quartiles of serum folate concentrations of 0.23 [95% confidence interval (CI) 0.09, 0.54] for the entire group, 0.27 (CI 0.09, 0.80) for the wild-type and 0.08 (CI 0.01, 0.52) for the heterozygous C677T genotype."
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Source: HighBeam Research, Increased serum folate levels associated with reduced breast cancer...