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Endocrinological underpinnings elucidated.
2004 AUG 5 - (NewsRx.com & NewsRx.net) -- The endocrinological factors underlying breast cancer have been elucidated.
"In breast tumors and breast cancer cell (BCC) lines, microarray analyses have revealed that a series of genes are expressed in close association with the estrogen receptor-alpha (ER-alpha) gene, ESR1," scientists in Belgium explained.
"Three of them, GATA3, HNF3A (also known as FOXA1), and XBP1 encode transcription factors" with "potential involvement in the ER-alpha-mediated actions in BCC," reported M. Lacroix and colleagues at the Free University of Brussels.
Experimental results revealed "relations that exist, or that might exist, between these factors and the estrogen-inducible trefoil factor TFF1," the researchers concluded.
Lacroix and coauthors published their study in Molecular and Cellular Endocrinology (About GATA3, HNF3A, and ...
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Source: HighBeam Research, Endocrinological underpinnings elucidated.