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Sexual behavior changes may explain rising incidence of anal cancer.
2004 AUG 5 - (NewsRx.com & NewsRx.net) -- Anal cancer is on the rise in both sexes, particularly among American men, and changing trends in sexual behavior - combined with current tobacco use and infection by a specific strain of the human papillomavirus (HPV) - may help explain the increase.
These findings, from two separate studies by researchers at Fred Hutchinson Cancer Research Center, are reported in a pair of papers in the July 15, 2004 issue of Cancer.
The first study, by lead author Lisa G. Johnson, PhD, a statistical-research associate in Fred Hutchinson's public health sciences division, found incidence rates of anal cancer have increased significantly in the past 30 years, jumping 160% in men and 78% in women.
The sharpest increase was among African-American men, whose incidence of anal cancer has more than doubled in the past 3 decades. Black men also had a lower survival rate from the disease. The 5-year survival rate for black men with early-stage disease was 62% as compared to 79% for white men with localized cancer.
The study, funded by the National Cancer Institute (NCI), was based on the records of 6093 anal-cancer patients (2888 men and 4015 women) diagnosed between 1973-2000. The data came from tumor registries in five states and four metropolitan areas that are part of the NCI Surveillance, Epidemiology and End Results program.
The second study, led by epidemiologist Janet Daling, PhD, a member of Fred Hutchinson's public health sciences division, set out to better understand the underlying biological and lifestyle causes behind the rising incidence of anal cancer.
The study tested for the presence of HPV - a well-known sexually transmitted viral marker of anal cancer - in both blood and tumor tissue. It also assessed the impact of various lifestyle factors associated with the disease, such as smoking, sexual orientation, number of sexual partners, and history of anal intercourse.
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Source: HighBeam Research, Sexual behavior changes may explain rising incidence of anal cancer.