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Methodological issues arising from reviews of vaccine safety outlined.

Vaccine Weekly

| August 04, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Scientists outline the methodological issues arising from systematic reviews of the evidence of safety of vaccines in a recent issue of Vaccine.

According to a study from England, "Adaptations to the recognized methods of systematic reviewing are required when addressing questions about safety, particularly about rare and/or long-term serious adverse events. Conducting a systematic review of vaccine safety requires the implementation of novel strategies for locating studies, the use of experimental instruments to assess the quality of non-randomized studies, and the employment of pooling methods for non-randomized data, where appropriate."

"Standardizing both the indexing of adverse event data on electronic libraries and their reporting would improve the potential of systematic reviews of vaccine to draw accurate conclusions about the safety of a vaccine," stated Deirdre ...

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