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Neonatal dendritic cells deficient in presentation of soluble antigen.
2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Murine neonatal dendritic cells are deficient in MHC class I cross-presentation of soluble antigen.
According to recent research from the United States, "Neonates respond suboptimally to many vaccines. The reasons for this defect are unclear, but suboptimal antigen presentation by dendritic cells has been suggested as one possibility. In this report we describe an in vitro system that allows the generation of large numbers of resting murine neonatal dendritic cells facilitating their study."
"Using this system, we show a clear reduction in the ability of neonatal dendritic cells to present soluble ovalbumin, while the capacity to present ovalbumin peptide is intact," reported Tobias R. Kollmann and colleagues at the University of Washington in Seattle. "This suggests a specific defect in cross-presentation of exogenous antigen via the major histocompatibility complex (MHC) class I pathway. ...
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Source: HighBeam Research, Neonatal dendritic cells deficient in presentation of soluble antigen.