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IgG1 suppression occurs with IL-6 overexpression in immunized mice.
2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Transient suppression of IgG1 occurs with IL-6 overexpression in immunized TCR-transgenic mice.
"Helper T cell-derived cytokines play a pivotal role in the production of antigen-specific IgG antibody by B cells. In order to examine the in vivo effect of massive activation of helper T cells on the production of specific antibodies, ovalbumin (OVA)-specific TCR transgenic mice (OVA23-3) were immunized with OVA and serum levels of antigen-specific antibodies were measured. As a result, a great enhancement of antigen-specific IgM secretion and delay of IgG secretion were observed while the T cells produced sufficient Th2 cytokines," scientists in Japan report.
"Immediately after OVA-immunization, marked increase of serum IL-6 was noted, which was followed by a transient increase of antibody forming cells," said Yoshie Kametani and colleagues at Tokai University. "Both in vivo and in vitro experiments demonstrated that excess amount of IL-6 enhanced IgM production by activated B cells while suppressing ...
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...Moll published the study in Immunology Letters (Dendritic cells as a tool...To subscribe to the journal Immunology Letters, contact the publisher...This article was prepared by Vaccine Weekly editors from staff and other...