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CD70 stimulation promotes strong cytotoxic T cell responses in vivo.
2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Stimulation by soluble CD70 promotes strong primary and secondary CD8+ cytotoxic T cell responses in vivo.
"Identification of the signals required for optimal differentiation of naive CD8+ T cells into effector and memory cells is critical for the design of effective vaccines. In this study we demonstrate that CD27 stimulation by soluble CD70 considerably enhances the magnitude and quality of the CD8+ T cell response. Stimulation with soluble CD70 in the presence of antigen significantly enhanced the proliferation of CD8+ T cells and their ability to produce IL-2 and IFN-gamma in vitro," scientists in England report.
"Administration of antigen and soluble CD70 resulted in a massive (>300-fold) expansion of antigen-specific CD8+ T cells in vivo, which was due to the enhanced proliferation and survival of activated T cells," said Tania F. Rowley and Aymen Al-Shamkhani at Southampton General Hospital. "In mice that received antigen and soluble CD70, CD8+ T cells developed into effectors with direct ex vivo cytotoxicity. Furthermore, unlike peptide immunization, which resulted in a diminished response after rechallenge, CD27 stimulation during the primary challenge evoked a strong secondary response upon ...
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