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Bilayer composition affects dendritic cell-liposome interactions.
2004 AUG 4 - (NewsRx.com & NewsRx.net) -- The bilayer composition affected the interactions of dendritic cells with antigen-containing liposomes.
"Vaccine efficacy might be improved by exploiting the potent antigen presenting properties of dendritic cells (DCs), since their ability to stimulate specific major histocompatibility complex-restricted immune responses has been well documented during the recent years. In that light, we investigated how the interaction of antigen-containing liposomes with DCs was affected by the bilayer composition. Monocyte-derived human DCs and murine bone marrow-derived DCs were analyzed and compared upon in vitro incubation with liposomes by flow cytometry and confocal microscopy," scientists writing in the journal Vaccine report.
"Anionic liposomes with a bilayer composition of phosphatidylcholine, cholesterol, and phosphatidylglycerol or phosphatidylserine interacted with a limited fraction of the total DC population in case of both DC types," said Camilla Foged at the Danish University of Pharmaceutical Sciences and collaborators in Denmark, Sweden, and the Netherlands. "Inclusion of mannosylated phosphatidylethanolamine (Man-PE) for targeting to the mannose receptor (MR) increased the interaction of negatively charged liposomes with both human and murine DCs."
"This increase could be blocked in ...
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...colleagues. The researchers concluded: "At a fixed bilayer composition, the transition temperature (> 338 K) from the...the Journal of Physical Chemistry B (The Influence of Bilayer Composition on the Gel to Liquid Crystalline Transition. Journal...
- Monomeric CYP 3A4 characterized in nanoscale membrane bilayer.
- Newspaper article from: Biotech Week December 8, 2004 700+ words
...reaction cycle." "In addition, these P450 monooxygenases are normally found in a membrane environment and the bilayer composition and dynamics can also effect these catalytic steps," noted B.J. Baas and colleagues at the University of...
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...process (E-a) was determined from DSC thermograms by four separate methods. Both T-m and Ea varied with bilayer composition. Cholesterol increased the T-m both the presence and absence of docosahexaenoic acid acyl chains (DHA...
- New pharmaceutical research reported from University of Manchester.
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...assemblies, including the effect of changing magnetic nanoparticle concentration, pH, adhesive lipid structure and bilayer composition," wrote R.J. Mart and colleagues, University of Manchester. The researchers concluded: "These investigations...
- Relaxometric properties of paramagnetic pH-responsive liposomes determined.
- Newspaper article from: Biotech Week June 9, 2004 700+ words
...a study conducted by K.E. Lokling and colleagues at the University of Oslo, the "effects of variations in bilayer composition on the relaxometric properties of diacylphosphatidylethanolamine (PE)/dipalmitoylglycerosuccinate (DPSG...
- University of Naples details research in Alzheimer disease.
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...spin-labeled on the acyl chain. The effect of inclusion of charged phospholipids or/and cholesterol in the bilayer composition was considered in relation to the peptide/membrane interaction. The results show that A beta(25-35) inserts...
- Studies from University of Western Ontario reveal new findings on physical...
- Newspaper article from: Chemicals & Chemistry August 28, 2009 700+ words
...dimyristoylphosphatidylcholine (DMPC) lipids. Using atomistic molecular dynamics simulations, we address the effects of bilayer composition (cationic to zwitterionic lipid fraction) and of NaCl electrolyte concentration on the dynamical properties...
- Data on biomembranes discussed by researchers at University of Twente.
- Newspaper article from: Life Science Weekly August 11, 2009 700+ words
...low ionic strength. The disruption of negatively charged vesicles further depends on lipid packing parameters. Bilayer composition changes that result in an increased lipid headgroup spacing make vesicles more prone to disruption, suggesting...
