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Antigen distribution in mono-valent and combination vaccines reported.
2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Researchers have determined the distribution of adsorbed antigen in mono-valent and combination vaccines.
According to recent research published in the journal Vaccine, "The distribution of alpha-casein, bovine serum albumin (BSA), myoglobin, and recombinant protective antigen (rPA) in mono-valent and combination vaccines containing aluminum hydroxide adjuvant was studied by fluorescence microscopy and flow cytometry. Green and red fluorescent probes were conjugated to the antigens. Adsorption isotherms of the fluorescently labeled proteins to aluminum hydroxide adjuvant demonstrated that incorporation of the fluorescent probe did not significantly affect the adsorption."
"In mono-valent vaccine systems, antigen adsorption occurred within one minute and uniform surface coverage of the adjuvant aggregates was observed within 1 hour," said Garry L. Morefield and colleagues at Purdue University. "Content uniformity was achieved through a cycle of de-aggregation and re-aggregation of the aluminum hydroxide adjuvant aggregates caused by mixing. For combination vaccines, two antigens were adsorbed separately to the aluminum hydroxide adjuvant prior to ...
- Aluminum hydroxide adjuvant induces macrophage differentiation.
- Newspaper article from: Health & Medicine Week November 1, 2004 700+ words
...amp; NewsRx.net) -- Aluminum hydroxide adjuvant induces macrophage differentiation...study the in vitro effect of aluminum hydroxide adjuvant on isolated macrophages. We showed...their study in Vaccine (Aluminum hydroxide adjuvant induces macrophage differentiation...
- Aluminum Hydroxide Adjuvant Up-Regulates Accessory Properties of Human...
- Newspaper article from: Vaccine Weekly February 21, 2001 700+ words
2001 FEB 21 - (NewsRx.com & NewsRx.net) -- by Michelle Marble, staff medical writer -- How aluminum adjuvants affect the immune system was explored by researchers in Sweden. "Aluminum adjuvants are widely used in human vaccines based on their ability to enhance antibody production," report
- Aluminum hydroxide adjuvant affects sensitization toward OVA inhalation.
- Newspaper article from: Vaccine Weekly April 9, 2003 700+ words
2003 APR 9 - (NewsRx.com & NewsRx.net) -- An aluminum hydroxide adjuvant was able to modulate the development of sensitization or tolerance following repeated OVA inhalation in BALB/cJ mice. "Anthropogenically...
- Antigen distribution in mono-valent and combination vaccines reported.
- Newspaper article from: Drug Week August 6, 2004 700+ words
...valent and combination vaccines containing aluminum hydroxide adjuvant was studied...aluminum hydroxide adjuvant aggregates...mixing. For combination vaccines, two antigens...aluminum hydroxide adjuvant prior to...
- Pseudolymphoma (first report with DT-poliovirus vaccine), due to aluminum...
- Magazine article from: Reactions Weekly Anonymous October 4, 2008 700+ words
DT-poliovirus vaccine/hepatitis B vaccine A woman developed subcutaneous pseudolymphoma after undergoing hepatitis B vaccination and DT-poliovirus vaccination with aluminum hydroxide as an adjuvant. At the age of 45 years, the woman presented with a 1 -year history of a firm subcutaneous
- Conference Coverage (ECPI Combination Vaccines) Many Hurdles for Successful...
- Newspaper article from: Vaccine Weekly June 8, 1998 700+ words
...take advantage of the trend toward combination vaccines must make similarly complex plans...development and implementation of combination vaccines," warned Ronald Ellis, senior...Information (ECPI) Rapid Development of Combination Vaccines Conference, held April 20-22...
- Many Hurdles for Successful Combination Vaccines.
- Newspaper article from: Vaccine Weekly June 8, 1998 700+ words
...take advantage of the trend toward combination vaccines must make similarly complex plans...development and implementation of combination vaccines," warned Ronald Ellis, senior...Information (ECPI) Rapid Development of Combination Vaccines Conference, held April 20-22...
- Combination vaccines: simpler or more complex?(Expert Commentary)
- Magazine article from: Family Practice News Pichichero, Michael E. July 1, 2007 700+ words
Combination vaccines make life easier for our patients...huge barrier to the use of all combination vaccines. Of course we all want to minimize...those efforts. With even more combination vaccines in the pipeline, the issue...
