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Toxin from Bordetella pertussis offers promise for antigen delivery.
2004 AUG 4 - (NewsRx.com & NewsRx.net) -- The adenylate cyclase toxin from Bordetella pertussis is a novel promising vehicle for antigen delivery to dendritic cells.
According to recent research from France, "Bordetella pertussis secretes an adenylate cyclase toxin (CyaA or ACT) that targets primarily cells expressing the alpha[subscript]Mbeta[subscript]2 integrin (CD11b/CD18) receptor. This toxin can deliver its N-terminal catalytic AC domain (400 amino acid residues) into the cytosol directly across the cytoplasmic membrane."
"Various heterologous CD8+, as well as CD4+ T-cell epitopes have been engineered into genetically detoxified CyaA and the resulting toxoids were successfully used as vectors for delivery of inserted epitopes into antigen-presenting cells," said M. Simsova and colleagues at the Institute Pasteur in Paris. "Upon processing and presentation, these recombinant CyaAs trigger specific MHC class I and/or class II-restricted T-cell responses both in vitro and ...
- Bordetella pertussis acts as adjuvant and inhibitor of immune responses.
- Newspaper article from: Drug Week April 23, 2004 700+ words
...com & NewsRx.net) -- Bordetella pertussis can act as adjuvant as well as inhibitor...OVA), formalin-inactivated Bordetella pertussis (Bp) augmented antibody responses...published their study in Vaccine (Bordetella pertussis can act as adjuvant as well as inhibitor...
- bvgR expression in Bordetella pertussis analyzed.
- Newspaper article from: Proteomics Weekly January 5, 2004 700+ words
...the analysis of bvgR expression in Bordetella pertussis in a recent issue of the Journal...research from the United States, "Bordetella pertussis, the causative agent of whooping...Analysis of bvgR expression in Bordetella pertussis. J Bacteriol, 2003;185(23...
- Rapid identification of Bordetella pertussis pertactin gene variants using...
- Magazine article from: Emerging Infectious Diseases Makinen, Johanna Viljanen, Matti K. Mertsola, Jussi Arvilommi, Heikki He, Qiushui November 1, 2001 700+ words
...pertactin gene (prn1-8) have been characterized in Bordetella pertussis strains isolated in Europe and the United States. It...sequencing in pertussis research. ********** Bordetella pertussis is the causative agent of pertussis (whooping cough...
- Changes in predominance and diversity of genomic subtypes of bordetella...
- Magazine article from: Emerging Infectious Diseases Hardwick, Terri Hawes Cassiday, Pamela Weyant, Robbin S. Bisgard, Kristine M. Sanden, Gary N. January 1, 2002 700+ words
...Pulsed-field gel electrophoresis (PFGE) of Bordetella pertussis chromosomal DNA fragments generated by Xbal restriction...cough, is an acute respiratory disease caused by Bordetella pertussis. Before pertussis vaccine was introduced in...
- Bordetella pertussis Goes to College.
- Magazine article from: Family Practice News Wang, Jennifer M. October 15, 2000 700+ words
Bordetella pertussis was responsible for 8% of illnesses with prolonged cough in 319 University of Washington students. Of the 26 B. pertussis cases...
- Bordetella pertussis isolates, Finland.(Letters)(Letter to the Editor)
- Magazine article from: Emerging Infectious Diseases Makinen, Johanna Mertsola, Jussi Mooi, Frits R. Van Amersfoorth, Shirley Arvilommi, Heikki Viljanen, Matti K. He, Qiushui January 1, 2005 700+ words
To the Editor: Pertussis, or whooping cough, is a highly contagious respiratory disease in humans caused by Bordetella pertussis. Reemergence of pertussis has been observed in many countries with high vaccination coverage. In the United States...
- The use of TaqMan PCR assay for detection of Bordetella pertussis infection...
- Magazine article from: Archives of Pathology & Laboratory Medicine Chan, Edward L. Antonishyn, Nick McDonald, Ryan Maksymiw, Tara Pieroni, Peter Nagle, Evelyn Horsman, Greg B. February 1, 2002 700+ words
...characterized by progressive, repetitive paroxysmal coughing; mild systemic complaints; and lymphocytosis. Bordetella pertussis does not survive well in the environment and is most likely spread from person to person during the incubation...
- Bordetella pertussis in adult pneumonia patients (1).(Letters)
- Magazine article from: Emerging Infectious Diseases Beynon, Kirsten A. Young, Sheryl A. Laing, Richard T.R. Harrison, Timothy G. Anderson, Trevor P. Murdoch, David R. April 1, 2005 700+ words
To the Editor: Although B. pertussis infection is well-characterized in children, the epidemiology and clinical spectrum of pertussis in adolescents and adults are less well defined. Instances of pneumonia complicating adult pertussis have been reported (1,2), yet the role of B. pertussis in adult
Source: HighBeam Research, Toxin from Bordetella pertussis offers promise for antigen delivery.