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Bacterial ghosts are an efficient delivery system for DNA vaccines.
2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Bacterial ghosts are an efficient delivery system for DNA vaccines.
According to a study from Germany, Austria, and Slovakia. "Mass implementation of DNA vaccines is hindered by the requirement of high plasmid dosages and poor immunogenicity. We evaluated the capacity of Mannheimia haemolytica ghosts as delivery system for DNA vaccines. In vitro studies showed that bacterial ghosts loaded with a plasmid carrying the green fluorescent protein-encoding gene (pEGFP-N1) are efficiently taken up by APC, thereby leading to high transfection rates (52-60%)."
"Vaccination studies demonstrated that ghost-mediated delivery by intradermal or i.m. route of a eukaryotic expression plasmid containing the gene coding for beta-galactosidase under the control of the CMV immediate early gene promoter (pCMVbeta) stimulates more efficient antigen-specific humoral and cellular (CD4+ and CD8+) immune responses than naked DNA in BALB/c mice," reported Thomas Ebensen at the German Research Center for Biotechnology and collaborators in Germany, Austria, and Slovakia. "The use of ghosts also allows modulating the major Th response from a mixed Th1/Th2 to a more dominant Th2 pattern."
"Intravenous immunization with dendritic cells loaded ex vivo with pCMVbeta-containing ghosts also resulted in the elicitation of beta-galactosidase-specific responses," stated the scientists. "This suggests that ...
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Source: HighBeam Research, Bacterial ghosts are an efficient delivery system for DNA vaccines.