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Molecular adjuvants for mucosal immunity reviewed.
2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Researchers review molecular adjuvants for mucosal immunity in a recent issue of Immunological Reviews.
According to a study from the United States, "Mucosal surfaces represent the entry route of a multitude of viral pathogens. For many of these viruses, such as the herpes simplex viruses and human immunodeficiency virus, no effective vaccine exists. Hence, it is important that prospective vaccines engender maximal immunity at these susceptible sites. Genetic vaccines encoding adjuvant molecules represent one approach to optimize mucosal as well as systemic immunity."
"Promising candidates include various inflammatory cytokines and chemokines that might be used to enhance the primary response to a level sufficient for protection," said Felix N. Toka and collaborators at the University of Tennessee. "Encouraging studies involving cytokines such as granulocyte/macrophage colony-stimulating factor, interleukin-2 (IL-2), IL-12, IL-18, and many others are examined. Notable chemokines that may offer hope in such efforts include IL-8, RANTES, CCL19, CCL21, and a few others. Combinatorial approaches utilizing several cytokines and chemokines will most likely yield the greatest success."
"In addition, as more is discovered ...
- Portal to the interior: viral pathogenesis and natural compounds that restore...
- Magazine article from: Alternative Medicine Review Williams, James E. November 1, 2003 700+ words
...against inflammation known to dampen mucosal immunity, promote carcinogenesis, contribute...against microbial infections. Since mucosal immunity forms the first line of defense against...pathogens, restoring and maintaining mucosal immunity is critical for disease prevention...
- Vaccines for mucosal immunity to combat emerging infectious diseases.
- Magazine article from: Emerging Infectious Diseases Van Ginkel, Frederik W. Nguyen, Huan H. McGhee, Jerry R. March 1, 2000 700+ words
...capable of inducing both systemic and mucosal immunity. Although numerous strategies exist...vaccine. The induction of protective mucosal immunity to influenza virus has made considerable...are in phase-3 clinical trials. Mucosal immunity, which is important for long-term...
- Galenica Pharmaceuticals Announces Collaboration With The University Of Alabama...
- Press release article from: PR Newswire May 9, 2001 700+ words
...immune enhancer adjuvant GPI-0100 on mucosal immunity. Under the terms of the agreement...The ability of GPI-0100 to enhance mucosal immunity would lead to the use of this compound...interested in learning about its effects on mucosal immunity. Therefore, these studies are ...
- Nasal Flt3 ligand cDNA elicits dendritic cells for enhanced mucosal immunity.
- Newspaper article from: Biotech Week May 5, 2004 700+ words
...CD8+ dendritic cells for enhanced mucosal immunity. "Nasal immunization is an effective...FL) for its potential to enhance mucosal immunity or tolerance. Interestingly, tolerance...CD8+ dendritic cells for enhanced mucosal immunity. J Immunol, 2004;172(6):3612...
- Induction of mucosal immunity could slow HIV transmission. (Second Annual...
- Newspaper article from: AIDS Weekly DeNoon, Daniel J. April 11, 1994 700+ words
...Despite major recent advances in the understanding of mucosal immunity, little is known about this first-line defense against...Biomedical researcher listed several current issues regarding mucosal immunity against HIV: * Some of the cytokines found in mucosal...
- Women, HIV, and mucosal immunity. (Periodical Report)
- Newspaper article from: AIDS Weekly April 29, 1991 700+ words
...vaccine research should focus on providing genital tract mucosal immunity, a British researcher argues. Bruce D. Forrest of the...immunoglobulin of the humoral immune system in the body. ... The mucosal immunity of the human female genital tract and its role in the prevention...
- Protection against HIV may require mucosal immunity.
- Newspaper article from: AIDS Weekly DeNoon, Daniel J. April 17, 1995 700+ words
Induction of mucosal immunity may be necessary for vaccine prevention of HIV infection...Genital IgG is locally produced. Paradoxically, induction of mucosal immunity is most effective at a mucosal site separate from the effector...
- Adjuvant provides mucosal immunity for Chlamydia trachomatis vaccine.
- Magazine article from: Women's Health Weekly February 6, 2003 700+ words
...published their study in the Journal of Immunology (GM-CSF transgene-based adjuvant allows the establishment of protective mucosal immunity following vaccination with inactivated Chlamydia trachomatis. J Immunol, 2002;169(11):6324-6331). For additional...
- Crossing the frontlines in mucosal immunity: how natural gut flora shape host...
- Magazine article from: The Scientist Schweitzer, A. Nicola July 19, 2004 700+ words
...Knight's and Macpherson's studies are important in demonstrating the involvement of intestinal flora in establishing mucosal immunity, says Fioramonti, and his own group's work shows that stress during the neonatal period can compromise these processes...
- Virus-like particle elicits mucosal immunity in male monkeys. (Ty-VLP)
- Newspaper article from: AIDS Weekly May 16, 1994 700+ words
...simian version of an HIV vaccine already in clinical trials offer hope that the vaccine could be used to stimulate powerful mucosal immunity. The experiments, conducted in male animals, offer hope that immunization could not only prevent genital transmission...
Source: HighBeam Research, Molecular adjuvants for mucosal immunity reviewed.