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T cells from Salmonella vaccine cause interclonal competition.
2004 AUG 4 - (NewsRx.com & NewsRx.net) -- A massive number of antigen-specific CD4 T cells during vaccination with live attenuated Salmonella causes interclonal competition.
"The clonal burst size of CD4 T cells is predicted to be less than that of CD8 T cells. In this study, we demonstrate that massive numbers of antigen-specific CD4 T cells respond during vaccination of mice with live attenuated Salmonella, reaching a peak frequency of (approx)50% of CD4 T cells," scientists in the United States report.
"Salmonella-specific T cells persisted at high frequency for several weeks and could be detected in the memory population for months after infection," stated Aparna Srinivasan and colleagues at the University of Connecticut. "Surprisingly, the expansion of endogenous Salmonella-specific CD4 T cells prevented the persistence of adoptively transferred Salmonella-specific T cells in vivo, demonstrating interclonal competition for access to the memory compartment."
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Source: HighBeam Research, T cells from Salmonella vaccine cause interclonal competition.