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Efficacies of pertussis vaccines against B. parapertussis compared.
2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Scientists have compared the efficacies of whole cell and acellular pertussis vaccines against Bordetella parapertussis in a mouse model.
According to a study from the Netherlands, "Pertussis vaccine development has mainly focused on Bordetella pertussis, and consequently these vaccines contain B. pertussis antigens only. However, the related species Bordetella parapertussis can also cause pertussis, although symptoms associated with the disease are generally considered to be milder. Recent field studies have shown that in some outbreaks B. parapertussis can prevail."
"Using a mouse model we compared the efficacy against B. parapertussis of two commercially available acellular vaccines and two whole cell vaccines, used in The Netherlands and Finland, respectively," said Silke David and collaborators at the National Institute of Public Health and the Environment and Leiden University. "The efficacies of the two whole cell vaccines against B. parapertussis were similar, but much lower compared to the efficacy against B. pertussis. Although, the acellular vaccines conferred some protection against B. parapertussis early in infection, the values were not significant."
The researchers reported, "Later ...
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