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Plasmodium vivax merozoite surface proteins possess immunogenicity.
2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Plasmodium vivax merozoite surface protein-9 recombinant proteins expressed in E. coli possess immunogenicity.
"Merozoite surface protein-9 of Plasmodium vivax (PvMSP-9) is highly conserved and present in several malaria species. Here, we present the immunogenic properties of two recombinant glutathione S-transferase (GST) fusion proteins comprising the N-terminus (PvMSP-9-Nt) and the second block of tandem repeats (PvMSP-9-RepII) of PvMSP9. These recombinants proteins were used to immunize BALB/c mice," scientists in the United States report.
"The specificity and subtyping of the antibodies and the cellular immune responses were evaluated by enzyme-linked immunosorbent assay (ELISA) and ELISPOT, respectively, using the recombinant proteins as antigens," said Joseli Oliveira-Ferreira and collaborators at Emory University and the U.S. Centers for Disease Control and Prevention. "Our results demonstrate that both the N-terminal and the tandem repeat regions of MSP9 are immunogenic in mice. The ELISA antibody titers elicited by PvMSP-9-Nt were significantly higher (1:819,200) than the antibody titers elicited by PvMSP-9-RII (1:409,600)."
"Analysis of IgG subclasses showed that both recombinant proteins induce similar antibody patterns where IgG1, IgG2a and IgG2b were most predominant," reported the researchers. "Moreover, all sera from mice immunized with either PvMSP-9-Nt or PvMSP-9-RII, which were positive by ELISA showed ...
- Biologics Pipelines: Who Has the Next Promising Recombinant Proteins?
- Press release article from: M2 Presswire May 2, 2008 700+ words
...Pipelines: Who Has the Next Promising Recombinant Proteins?(C)1994-2008 M2 COMMUNICATIONS...Pipelines: Who Has the Next Promising Recombinant Proteins? to their offering. Therapeutic...development of multiple types of recombinant proteins. Success in future therapeutic...
- Tailor-Made Recombinant Proteins in Mammals; Aldehyde Tags Put Chemical...
- News wire article from: Ascribe Higher Education News Service February 9, 2009 700+ words
...modifications to specific sites on recombinant proteins - including the monoclonal antibodies...which they previous developed for recombinant proteins expressed in bacteria, to label...pinpointing chemical reactions to sites on recombinant proteins from /E. coli/, Bertozzi and...
- Modified peptides and recombinant proteins derived from the major bee venom.
- Newspaper article from: Immunotherapy Weekly May 14, 2003 700+ words
...net) -- Modified peptides and recombinant proteins are derived from the major bee venom...This led us to design peptides and recombinant proteins derived from the major bee venom...Clinique (Modified peptides and recombinant proteins derived from the major bee venom...
- Meridian Signs Agreement in Principle to Acquire Line of Recombinant Proteins...
- Press release article from: Business Wire May 13, 2008 700+ words
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- Gradipore and Biomira Collaborate for Separation and Purification of...
- Press release article from: PR Newswire February 10, 2002 700+ words
...the separation and purification of recombinant proteins based upon Gradipore's platform...isolating and purifying certain recombinant proteins. Gradipore scientists will establish...process for producing higher yields of recombinant proteins. Dr. Hari Nair, CEO of Gradipore...
- Recombinant proteins from plants; methods and protocols.(Brief article)(Book...
- Magazine article from: SciTech Book News March 1, 2009 700+ words
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- Recombinant proteins shown to be effective alternative to antibiotic use in...
- Magazine article from: Feedstuffs June 24, 2002 700+ words
The recombinant proteins lactoferrin and lysozyme, fed as an alternative to the use of...development-stage biotechnology company engaged in the production of recombinant proteins that have applications in human and animal health.
- Recombinant Proteins Shown to Be an Effective Alternative to Antibiotic Use In...
- Press release article from: PR Newswire June 13, 2002 700+ words
...the publication of research relating to the use of its recombinant proteins, lactoferrin and lysozyme, as an alternative to the...stage biotechnology company engaged in the production of recombinant proteins that have applications in human and animal health. Some...