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HSP70 mutants separate antigen delivery from DC stimulation.
2004 AUG 4 - (NewsRx.com & NewsRx.net) -- HSP70 peptide binding mutants separate antigen delivery from dendritic cell (DC) stimulation.
"Microbial heat shock proteins (HSPs) have been implicated in the induction of both the innate and adaptive arms of the immune response. We now show that human dendritic cells (DC) pulsed with peptide-loaded mycobacterial HSP70 complexes generate potent antigen-specific cytotoxic lymphocyte (CTL) responses, which are dependent on an HSP70-stimulated calcium signaling cascade. From the calculated peptide binding affinity of mycobacterial HSP70 (K[subscript]d=14 micromolar) we show that 120 pM HSP70 bound peptide is sufficient to generate a peptide-specific CTL response that is up to four orders of magnitude more efficient than peptide alone," scientists in England and Germany report.
"The minimal 136 amino acid, mycobacterial HSP70 peptide binding domain can generate CTL responses, and a single amino acid mutant HSP70 designed to prevent peptide binding but retain stimulatory capacity has allowed us ...
- HSP70 mutants separate antigen delivery from DC stimulation.
- Newspaper article from: Obesity, Fitness & Wellness Week August 7, 2004 700+ words
...peptide binding mutants separate antigen delivery from dendritic cell...capacity has allowed us to separate antigen delivery from DC immunostimulation...peptide binding mutants separate antigen delivery from dendritic cell stimulation...
- Vaccine Antigen Delivery Technologies - Molecular Systems to Open New Markets.
- Press release article from: M2 Presswire June 12, 2009 700+ words
...2009-Research and Markets: Vaccine Antigen Delivery Technologies - Molecular Systems to...announced the addition of the "Vaccine Antigen Delivery Technologies - Molecular Systems to...antigens, there is a need for novel antigen delivery technologies to improve vaccine efficacy...
- Research and Markets: Vaccine Antigen Delivery Technologies - Molecular Systems...
- Press release article from: Business Wire June 12, 2009 700+ words
...announced the addition of the "Vaccine Antigen Delivery Technologies - Molecular Systems to...antigens, there is a need for novel antigen delivery technologies to improve vaccine efficacy...technologies and products for vaccine antigen delivery. It provides an overview of ...
- Antigen delivery by polylactide co-glycolide microparticles developed.
- Newspaper article from: Health & Medicine Week June 14, 2004 700+ words
...net) -- Researchers have designed antigen delivery systems using charged polylactide...established in the last decade as potent antigen delivery systems and adjuvants, with experience...polylactide co-glycolide microparticles as antigen delivery systems. Expert Opin Biol Ther...
- Salmonella type III-mediated antigen delivery induces CTL-mediated...
- Newspaper article from: Vaccine Weekly January 22, 2003 700+ words
...is a useful tool for heterologous antigen delivery by attenuated Salmonella vaccine carrier...significantly surpassed single cytosolic antigen delivery in the ability to protect against...Salmonella type III-mediated heterologous antigen delivery for the induction of cytotoxic T...
- Complex-based antigen delivery effective against RSV infection in neonates.
- Newspaper article from: Health & Medicine Week August 23, 2004 700+ words
...immune-stimulating complex-based antigen delivery system for neonatal immunization against...Thus, the identification of hRSV antigen delivery systems with an age-appropriate...immune-stimulating complex-based antigen delivery systems for neonatal immunization...
- In vivo antigen delivery by a Salmonella typhimurium type III secretion system...
- Magazine article from: Journal of Clinical Investigation Nishikawa, Hiroyoshi Sato, Eiichi Briones, Gabriel Chen, Li-Mei Matsuo, Mitsutoshi Nagata, Yasuhiro Ritter, Gerd Jager, Elke Nomura, Hideki Kondo, Shigeto Tawara, Isao Kato, Takuma Shiku, Hiroshi Old, Lloyd J. Galan, Jorge E. Gnjatic, Sacha July 1, 2006 700+ words
...may offer many advantages over other antigen delivery systems for cancer vaccines. We engineered...epitope spreading. We propose that antigen delivery through the S. typhimurium type III...made S. typhimurium a very versatile antigen delivery platform (18, 19). Its intracellular...
- Spore germination provides novel route for antigen delivery.
- Newspaper article from: Health & Medicine Week January 26, 2004 700+ words
...provides a novel route for heterologous antigen delivery. According to recent research from...exploited this attribute for heterologous antigen delivery in this work," reported Le H. Duc...provides a novel route for heterologous antigen delivery. Vaccine, 2003;21(27-30...