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Live and inactivated hepatitis A vaccines induced immunity in children.

Vaccine Weekly

| August 04, 2004 | COPYRIGHT 2004 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Live attenuated and inactivated hepatitis A vaccines induced anti-HAV immune responses in children.

"The immunogenicity of a live attenuated HAV vaccine and an inactivated HAV vaccine was compared. Altogether 117 children were vaccinated with either the inactivated or the live attenuated vaccine. Children were bled at months 1, 6, 7, 12, and 24, and the anti-HAV total IgG antibody and IgG subclass profile were assessed," researchers in China report.

"In both vaccinated groups, the geometric mean titer (GMT) of anti-HAV peaked 7 months after the initial dose and declined during the following months," said Xuan-Yi Wang and colleagues at Fudan University. "The IgG subclass profiles in both vaccinated groups were highly restricted to IgG1 and IgG3. Both vaccines have been shown highly effective in preventing viral hepatitis A in former studies."

Wang ...

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