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Microparticles act as carriers to deliver plasmid DNA in vaccines.
2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Cross-linked microparticles act as carriers for the delivery of plasmid DNA for vaccine development.
According to a study from the United States, "Plasmid DNA was directly encapsulated into biocompatible polymer microparticles via radical polymerization in an inverse emulsion system. Acrylamide-based microspheres 0.2-1 micrometer in diameter were prepared using an acid-cleavable difunctional monomer. Retention of the DNA payload at physiological pH with complete release under acidic conditions at lysosomal pH was demonstrated. By trapping the plasmid DNA within the cross-linked microparticle, enzymatic degradation was prevented when exposed to serum nucleases."
"For vaccine development, these delivery vehicles were also investigated for their ability to generate immune responses when delivered to phagocytic cells of the immune system," stated Sarah L. Goh and colleagues at the University of California-Berkeley. "Encapsulated plasmid DNA demonstrated immunostimulatory activity in ...
- Microparticles act as carriers to deliver plasmid DNA in vaccines.
- Newspaper article from: Biotech Week August 4, 2004 700+ words
...carriers for the delivery of plasmid DNA for vaccine development. According to a study from the United States, "Plasmid DNA was directly encapsulated...carriers for the delivery of plasmid DNA for vaccine development. Bioconjugate Chemistry...
- Inoculation of plasmid DNA induced expression of LacZ gene.
- Newspaper article from: Biotech Week June 23, 2004 700+ words
...of beta-gal by the plasmid DNA is limited in the muscle...gene inserted in the plasmid DNA for immunotherapy...intramuscular inoculation of a plasmid DNA. J Vet Med Sci, 2004...areas of DNA Vaccine, Vaccine Development, Immunology, and...
- Polycation-mediated precipitation captures plasmid DNA from alkaline lysate.
- Newspaper article from: Health & Medicine Week November 1, 2004 700+ words
...precipitation captures plasmid DNA from alkaline lysate...polycation and the plasmid DNA resulted in the formation...in purification of plasmid DNA from a clarified lysate...major subject areas of Vaccine Development, Biotechnology...
- Microparticle adjuvant formulation for plasmid DNA vaccines characterized.
- Newspaper article from: Vaccine Weekly September 1, 2004 700+ words
...adjuvant formulation for plasmid DNA vaccines. "We describe...immunological evaluation of plasmid DNA vaccine formulations containing...adjuvant formulation for plasmid DNA vaccines. J Pharm Sci...Adjuvant, DNA Vaccine, Vaccine Development, Immunology, and ...
- Plasmid DNA activates dendritic cells via toll-like receptor 9.
- Newspaper article from: Biotech Week January 21, 2004 700+ words
...Vaccination with plasmid DNA activates dendritic...repeated vaccination with plasmid DNA, priming of OVA...Vaccination with plasmid DNA activates dendritic...areas of DNA Vaccine, Vaccine Development, Immunotherapy...
- M. leprae Hsp65-encoding plasmid DNA induces anti-mycobacterial immunity.
- Newspaper article from: Drug Week March 19, 2004 700+ words
...cutaneous injection of a plasmid DNA encoding a mycobacterial...coverage with candidate plasmid DNA vaccines, especially...leprae Hsp65-encoding plasmid DNA in biodegradable microparticles...Immunology, Immunotherapy, Vaccine Development, Vaccine Delivery...
- Plasmid DNA vaccine protects against aerosolized anthrax spores.
- Newspaper article from: Pharma Business Week November 29, 2004 700+ words
...lipid-formulated plasmid DNA vaccine confers sustained...and bivalent anthrax plasmid DNA (pDNA) vaccines encoding...lipid-formulated plasmid DNA vaccine confers sustained...of Anthrax Vaccine, Vaccine Development, DNA Vaccine, Vaccine...
- Plasmid DNA vaccination suppresses development of arthritis.
- Newspaper article from: Vaccine Weekly April 30, 2003 700+ words
...boost vaccination with plasmid DNA encoding caprine...goats with pUC-based plasmid DNA expressing CAEV env...boost vaccination with plasmid DNA encoding caprine...Therapy, DNA Vaccine, Vaccine Development, and Immunology...