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TCR DNA vaccine induces humoral response for lymphoma beta chain.
2004 AUG 4 - (NewsRx.com & NewsRx.net) -- A TCR DNA vaccine induced a humoral immunoreaction for the beta chain of T cell lymphoma.
According to published research from China, "We exploited the humoral immunoreaction of mice induced by TCR DNA vaccine of the beta chain of T cell lymphoma. The plasmids of pcDNA3.1/TCR V beta 8 was constructed. The BALB/c mice were randomly divided into four groups which were pcDNA3.1, pcDNA3.1/TCR V beta 8, pcDNA3.1/TCR V beta 8 + CpG + liposome, and phosphorothioate CpG groups with six mice in each group. Vaccines were injected in bilateral musculus quadriceps femoris of mice in the zeroth, second, and fourth week, respectively."
"The antibody formation was tested by indirect immunofluorescence in the zeroth, second, fourth, sixth and eighth weeks, respectively, before and after immunization," said Mingzhi Zhang and colleagues at Zhengzhou University. "Production of antibody against TCR V beta 8 antigen was observed in the groups of pcDNA3.1/TCR V beta 8 and pcDNA3.1/TCR V beta 8 + CpG + liposome. The antibody titer began to rise in the fourth week and attain the maximal value in the sixth week."
"The antibody titer in the group of pcDNA3.1/TCR V beta 8 + CpG + liposome was higher than that in the group of pcDNA3.1/TCR V beta 8 in the fourth and ...
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Source: HighBeam Research, TCR DNA vaccine induces humoral response for lymphoma beta chain.