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NY-ESO-1-related HLA A2-restricted epitopes characterized.
2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Researchers have determined the functional and structural characteristics of NY-ESO-1-related HLA A2-restricted epitopes.
According to a study from Australia, "NY-ESO-1, a commonly expressed tumor antigen of the cancer-testis family, is expressed by a wide range of tumors but not found in normal adult somatic tissue, making it an ideal cancer vaccine candidate. Peptides derived from NY-ESO-1 have shown preclinical and clinical trial promise; however, biochemical features of these peptides have complicated their formulation and led to heterogeneous immune responses. We have taken a rational approach to engineer an HLA A2-restricted NY-ESO-1-derived T cell epitope with improved formulation and immunogenicity to the wild type peptide."
"To accomplish this, we have solved the X-ray crystallographic structures of HLA A2 complexed to NY-ESO (157-165) and two analogues of this peptide in which the C-terminal cysteine residue has been substituted to alanine or serine," reported Andrew I. Webb at Monash University and collaborators in Australia. "Substitution of cysteine by serine maintained peptide conformation yet reduced complex stability, resulting in poor cytotoxic T lymphocyte recognition. Conversely, substitution with alanine maintained complex stability and cytotoxic T lymphocyte recognition."
"Based on the structures of the three HLA A2 complexes, we incorporated ...
- Lentiviral vector encoding NY-ESO-1 induces effective CTL response.
- Newspaper article from: Cancer Weekly March 30, 2004 700+ words
...injection of a lentiviral vector encoding NY-ESO-1 induces an effective cytotoxic...vector encoding the melanoma antigen NY-ESO-1 in HLA-A2 transgenic mice. Direct iv injection of NY-ESO-1 lentivirus induced NY-ESO-1...
- NY-ESO-1 protein protects against NY-ESO-1+ tumors.
- Newspaper article from: Obesity, Fitness & Wellness Week June 26, 2004 700+ words
...NewsRx.com & NewsRx.net) -- NY-ESO-1 protein formulated in ISCOMATRIX...mediated immunity and protection against NY-ESO-1+ tumors. According to a study from Australia, "NY-ESO-1 is a 180 amino-acid human tumor...
- NY-ESO-1 shows promise as antigen for breast cancer vaccine development.
- Newspaper article from: Biotech Week May 12, 2004 700+ words
...NewsRx.com & NewsRx.net) -- NY-ESO-1 shows promise as an antigen for...in the journal Cancer Research, "NY-ESO-1 is a cancer/testis antigen expressed...cellular immunity in patients with NY-ESO-1-expressing cancer. "The aim...
- Cytotoxic T cell responses toward NY-ESO-1 protein examined.
- Newspaper article from: Health & Medicine Week December 27, 2004 700+ words
...cytotoxic T cell responses toward the NY-ESO-1 protein by peptide/MHC-specific...European Journal of Immunology. "NY-ESO-1 is a germ-cell antigen aberrantly...cells generated in vaccine trials using NY-ESO-1-derived peptides (157-165...
- NY-ESO-1 is promising target for NSCLC immunotherapy.
- Newspaper article from: Biotech Week June 9, 2004 700+ words
...amp; NewsRx.net) -- The antigen NY-ESO-1 is frequently expressed by non...oncologists in Japan explained. "NY-ESO-1 is one of the most immunogenic...examined "mRNA expression status of NY-ESO-1 in 63 cases of NSCLCs using the...
- NY-ESO-1-related HLA A2-restricted epitopes characterized.
- Newspaper article from: Proteomics Weekly August 2, 2004 700+ words
...functional and structural characteristics of NY-ESO-1-related HLA A2-restricted epitopes...According to a study from Australia, "NY-ESO-1, a commonly expressed tumor antigen...vaccine candidate. Peptides derived from NY-ESO-1 have shown preclinical and clinical...
- Vaccine targets ovarian-cancer cells.(BIOMEDICINE)(NY-ESO-1 protein)(Brief...
- Magazine article from: Science News August 25, 2007 700+ words
...cancer. The protein fragment, called NY-ESO-1, appears on the surface of tumor...women received shots containing the NY-ESO-1 vaccine every 3 weeks for a period...primed to attack anything sporting NY-ESO-1. A few of the patients also developed...
- Therion Biologics and the Ludwig Institute Initiate Clinical Study of Cancer...
- Press release article from: PR Newswire January 2, 2002 700+ words
...vaccine targeting the tumor antigen NY-ESO-1. In this study, the Ludwig Institute...evaluate the potential benefits of NY-ESO-1 immunotherapy in cancer patients...products for the treatment of cancer." NY-ESO-1 Study Design The Phase I dose...
- Ruidos de la Calle / Cronicas de NY.(Cultura)
- Newspaper article from: Reforma (México D.F., México) November 12, 1999 700+ words
...importante, como el Time Out de NY, y superamos los 2 mil 500. Por...vender. Hay casi 1000 jardines en NY, algunos ya estn asegurados ante...esta apoyando los jardines, por eso llegaron personas de todo NY, de New Jersey, de Coney Island...
- Avidex Ltd establishes research collaboration with Ludwig Institute for Cancer...
- News wire article from: Asia Africa Intelligence Wire March 15, 2005 700+ words
...based on one of Avidex's soluble monoclonal T cell receptors, which targets the tumour-associated antigen NY-ESO-1. NY-ESO-1 was discovered by researchers at the LICR and is one of the most immunogenic tumour antigens known. It is...
Source: HighBeam Research, NY-ESO-1-related HLA A2-restricted epitopes characterized.