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DNA fusion gene vaccines against cancer reviewed.
2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Investigators review DNA fusion gene vaccines against cancer in a recent issue of Immunological Reviews.
"Vaccination against target antigens expressed by cancer cells has now become a realistic goal. DNA vaccines provide a direct link between identification of genetic markers in tumors and vaccine formulation. Simplicity of manufacture facilitates construction of vaccines against disease subsets or even for individual patients," scientists in England report.
"To engage an immune system that exists to fight pathogens, we have developed fusion gene vaccines encoding tumor antigens fused to pathogen-derived sequences," said Freda K. Stevenson and colleagues at Southampton University Hospital. "This strategy activates high levels of T-cell help, the key to induction and maintenance of effective immunity. We have dissected the immunogenic tetanus toxin to obtain specific sequences able to activate antibody, CD4+, or CD8+ T cells to attack selected fused tumor antigens. Principles established in preclinical models are now being tested in patients."
"So far, objective immune responses against idiotypic antigen of neoplastic B cells have been observed in patients with B-cell malignancies and in normal transplant donors," stated ...
- Crucell Awarded Contracts of Over $230 Million for Quinvaxem(TM) and...
- News wire article from: Europe Intelligence Wire December 1, 2006 700+ words
(From Hugin) PRESS RELEASE Crucell Awarded Contracts of Over $230 Million for Quinvaxem(TM) and Hepavax-Gene Vaccines Leiden, The Netherlands, December 1, 2006 - Dutch biotechnology company Crucell N.V. (Euronext, NASDAQ: CRXL...
- Crucell wins over 230 mln usd contracts for Quinvaxem, Hepavax-Gene vaccines.
- News wire article from: Europe Intelligence Wire December 1, 2006 700+ words
(From AFX Europe (Focus)) AMSTERDAM (AFX) - Dutch biotechnology company Crucell NV said it was awarded contracts totaling over 230 mln usd for its Quinvaxem and Hepavax-Gene paediatric vaccines by supranational organizations. The contracts span the three years to 2009, with the awarded amount
- Researchers at National Human Genome Research Institute target enzyme research.
- Newspaper article from: Blood Weekly April 2, 2009 700+ words
...detailed in a study published in Immunological Reviews. According to recent research...colleagues published their study in Immunological Reviews (Tec kinases regulate T-lymphocyte...the roles of Itk and Rlk/Txk. Immunological Reviews, 2009;228(1):93-114...
- Scientists at University of Texas, M.D. Anderson Cancer Center target enzyme...
- Newspaper article from: Blood Weekly April 2, 2009 700+ words
...writing in the journal Immunological Reviews report (see also Enzyme...published their study in Immunological Reviews (CARMA1-mediated...activation in lymphocytes. Immunological Reviews, 2009;228(1...
- Data from National Institute of Arthritis and Musculoskeletal and Skin Disease...
- Newspaper article from: Blood Weekly April 2, 2009 700+ words
...is newly published data in Immunological Reviews. "The Janus family kinases...colleagues published their study in Immunological Reviews (Janus kinases in immune cell signaling. Immunological Reviews, 2009;228(1):273...
- New data from Medical Research Council National Institute for Medical Research...
- Newspaper article from: Life Science Weekly March 31, 2009 700+ words
...colleagues published their study in Immunological Reviews (T-cell receptor proximal signaling...differentiation, and tolerance. Immunological Reviews, 2009;228(1):9-22...contact information for the journal Immunological Reviews is: Blackwell Publishing Inc...
- Dendritic cells and immunity to cellular antigens reviewed.
- Newspaper article from: Biotech Week July 21, 2004 700+ words
...cellular antigens in a recent issue of Immunological Reviews. According to a study from Australia...coauthors published their review in Immunological Reviews (Cross-presentation, dendritic...The publisher of the journal Immunological Reviews can be contacted at: Blackwell...
- Processing of antigens delivered as DNA vaccines reviewed.
- Newspaper article from: Drug Week July 23, 2004 700+ words
...DNA vaccines in a recent issue of Immunological Reviews. According to a study from England...Elliott published their review in Immunological Reviews (The processing of antigens delivered...contact information for the journal Immunological Reviews is: Blackwell Munksgaard, 35...
- Antigen-immunostimulatory oligonucleotide conjugates reviewed.
- Newspaper article from: Drug Week July 23, 2004 700+ words
...conjugates are reviewed in the journal Immunological Reviews. "Conjugation of protein antigen...associates published their study in Immunological Reviews (Antigen-immunostimulatory oligonucleotide...contact information for the journal Immunological Reviews is: Blackwell Munksgaard, ...
- Studies from Clinical Research Institute of Montreal yield new data on...
- Newspaper article from: Blood Weekly April 2, 2009 700+ words
...colleagues published their study in Immunological Reviews (PEST family phosphatases in immunity...and autoinflammatory disorders. Immunological Reviews, 2009;228(1):312-24...contact information for the journal Immunological Reviews is: Blackwell Publishing Inc...
Source: HighBeam Research, DNA fusion gene vaccines against cancer reviewed.