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Autologous lymphoma vaccines induce T cell responses against epitopes.
2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Autologous lymphoma vaccines induce human T cell responses against multiple, unique epitopes.
"The clonotypic surface Ig receptor expressed by malignant B cells, idiotype, is a tumor-specific antigen and an attractive target for active immunotherapy. While antibodies specific for tumor idiotype have been well described in patients with B cell malignancies, the precise antigenic epitopes in human idiotype recognized by autologous T cells remain largely unknown. We report here that T cell lines generated from lymphoma patients actively immunized with idiotype protein specifically recognized multiple, unique immunodominant epitopes in autologous tumor idiotype," scientists in the United States report.
"Synthetic peptides corresponding to hypervariable, but not framework, regions of Ig heavy chain specifically stimulated CD4+ and CD8+ T cells to proliferate and secrete proinflammatory cytokines in an MHC-associated manner," said Sivasubramanian Baskar and colleagues at the National Cancer Institute. "Detailed analysis revealed a minimal determinant of an immunodominant epitope, comprising critical residues at the amino terminus that may be a product of somatic hypermutation."
"Association of idiotype-specific T cell responses with previously documented molecular remissions in idiotype-vaccinated patients suggests ...
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Source: HighBeam Research, Autologous lymphoma vaccines induce T cell responses against epitopes.