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Vaccination with botulinum neurotoxin fragments prevents botulism.
2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Vaccination with botulinum neurotoxin fragments prevents botulism.
"Mice and ducks were subcutaneously immunized with recombinant whole heavy (H) chains of Clostridium botulinum type C and D neurotoxins, which were expressed as glutathione S-transferase fusion proteins. In the case of mice, it was confirmed that two immunizations with type C- and D-H chains, 10 mcg each time, significantly increased the specific antibodies against 100-kDa H chains of type C and D neurotoxins in an immunoblot analysis and an enzyme-linked immunosorbent assay, respectively," investigators in Japan report.
"The mice immunized with type G and D-H chains showed no symptoms of botulism when they were challenged with C- and D-16 S toxins at doses, given intraperitoneally, of up to 10[superscript]5 and 10[superscript]6 minimum lethal doses (MLD), respectively, per mouse," said Hideyuki Arimitsu at Okayama University and collaborators in Japan. "Ducks were immunized with a total of 100 mcg of type C-H chain. The ducks also developed specific antibodies to the type C-H chain and showed significant protection against a challenge with 10[superscript]3 duck MLD of C-16 S toxin ...
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Source: HighBeam Research, Vaccination with botulinum neurotoxin fragments prevents botulism.