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Thymosin alpha 1 activates dendritic cells for antifungal resistance.
2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Thymosin alpha 1 activates dendritic cells for antifungal Th1 resistance through Toll-like receptor signaling.
"Dendritic cells (DCs) show a remarkable functional plasticity in the recognition of Aspergillus fumigatus and orchestrate the antifungal immune resistance in the lungs. Here, we show that thymosin alpha1, a naturally occurring thymic peptide, induces functional maturation and interleukin-12 production by fungus-pulsed DCs through the 038 mitogen-activated protein kinase/nuclear factor (NF)-kappaB-dependent pathway. This occurs by signaling through the myeloid differentiation factor 88-dependent pathway, involving distinct Toll-like receptors," scientists in Italy report.
"In vivo, the synthetic peptide activates T-helper (Th) cell 1-dependent antifungal immunity, accelerates myeloid cell recovery, and protects highly susceptible mice that received hematopoietic transplants from aspergillosis," said Luigina Romani and colleagues at the University of Perugia. "By revealing the unexpected activity of an old molecule, our finding provides the rationale for ...
- Expression of toll-like receptors (TLRs) and Nucleotide-binding Oligomerization...
- Magazine article from: American Journal of Immunology Tarang, Shikha Sodhi, Ajit January 1, 2007 700+ words
Abstract: Thymosin [alpha] 1 (T[alpha...activation; TLRs; Thymosin [alpha] 1; Cytokines INTRODUCTION...Mycobacteria [17,18]. Thymosin [alpha] 1 (T[alpha...antifungal resistance in dendritic cells (DCs). T[alpha...
- Italian Researchers Report Statistically Significant Results in Hepatitis B...
- Press release article from: PR Newswire October 15, 1996 700+ words
...Study Also Reports Strong Results for Thymosin Alpha 1 in Combination with Low Dose Natural...reported today that its lead product, thymosin alpha 1, achieved statistically significant...evaluate the efficacy and safety of thymosin alpha 1 treatment in patients who were hepatitis...
- ITALIAN SCIENTISTS REPORT PRELIMINARY RESULTS FROM THYMOSIN ALPHA 1 HEPATITIS B...
- Press release article from: PR Newswire April 7, 1992 700+ words
...SCIENTISTS REPORT PRELIMINARY RESULTS FROM THYMOSIN ALPHA 1 HEPATITIS B CLINICAL TRIAL WASHINGTON...14 chronic hepatitis B patients with Thymosin alpha 1 or interferon were presented at the...months. Six of the seven (86 percent) Thymosin alpha 1 treated patients lost the hepatitis...
- THYMOSIN ALPHA 1 COMBINATION STUDY SUGGESTS CD4+ RESPONSE
- Press release article from: PR Newswire February 28, 1994 700+ words
...of treatment with the company's Thymosin alpha 1 drug plus AZT and alpha interferon...treatment regimens: AZT alone; AZT plus Thymosin alpha 1; AZT plus alpha interferon; and AZT plus Thymosin alpha 1 plus alpha interferon. Of 28 patients...
- SCICLONE PHARMACEUTICALS TO USE NEW CLINICAL DATA CONFIRMING THYMOSIN ALPHA 1'S...
- Press release article from: PR Newswire April 14, 1992 700+ words
...TO USE NEW CLINICAL DATA CONFIRMING THYMOSIN ALPHA 1'S SUPERIOR EFFECTIVENESS IN TREATING...published Italian study of the use if thymosin alpha 1 to treat chronic hepatitis B in regulatory...Diseases of the Liver, and showed that thymosin alpha 1 was twice as effective as alpha ...
- FIRST REGULATORY APPROVAL FOR THYMOSIN ALPHA 1
- Press release article from: PR Newswire May 15, 1992 700+ words
FIRST REGULATORY APPROVAL FOR THYMOSIN ALPHA 1 WASHINGTON, May 15 /PRNewswire...P.A. (Siena, Italy), that Thymosin alpha 1 has received approval from the Italian...regulatory approval in any country for Thymosin alpha 1. Prior to actual sales in Italy...
- Thymosin alpha 1 combination study suggests CD4+ response. (Maryland)
- Newspaper article from: AIDS Weekly March 14, 1994 700+ words
...of treatment with the company's thymosin alpha 1 drug plus AZT and alpha interferon...treatment regimens: AZT alone; AZT plus thymosin alpha 1; AZT plus alpha interferon; and AZT plus thymosin alpha 1 plus alpha interferon. Of 28 patients...
- SciClone Reports Antiviral Effects of ZADAXIN(R) Thymosin Alpha 1 at...
- Press release article from: PR Newswire December 22, 1997 700+ words
...today that its lead drug, ZADAXIN thymosin alpha 1, demonstrated a significant and...Hepatitis in Hawaii. Treatment with thymosin alpha 1 significantly reduced total viral...by 40%. "The antiviral effect of thymosin alpha 1 appears to be different from that...
- ALPHA 1 BIOMEDICALS, INC. ANNOUNCES PUBLICATION OF PRICE APPROVAL OF THYMOSIN...
- Press release article from: PR Newswire April 16, 1993 700+ words
...has published the official price for Thymosin alpha 1 in the Gazzetta Ufficiale, a newspaper...returns. Approval for marketing of Thymosin alpha 1 in Italy is expected within the next...had received preliminary approval for Thymosin alpha 1 from the Italian Ministry of Health...
- ITALIAN RESEARCHERS REPORT PROMISING RESULTS IN PHASE III STUDY OF THYMOSIN...
- Press release article from: PR Newswire July 11, 1996 700+ words
...Vancouver, provides further evidence that thymosin alpha 1 can influence the immune system in...intramuscularly twice per week plus 2 mg of thymosin alpha 1 subcutaneously twice per week (Group...combination of AZT, interferon alpha, and thymosin alpha 1 achieved a clinically ...
Source: HighBeam Research, Thymosin alpha 1 activates dendritic cells for antifungal resistance.