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Sendai virus expressing RSV glycoprotein elicits immune protection.
2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Recombinant Sendai virus expressing the G glycoprotein of respiratory syncytial virus (RSV) elicits immune protection against RSV.
According to a study from the United States, "Although RSV causes serious pediatric respiratory disease, an effective vaccine does not exist. To capture the strengths of a live virus vaccine, we have used the murine parainfluenza virus type I (Sendai virus [SV]) as a xenogeneic vector to deliver the G glycoprotein of RSV. It was previously shown that intranasal SV protected African green monkeys from challenge with the related human parainfluenza virus type 1 (hPIV1), and SV has advanced to clinical trials as a vaccine for hPIV1."
"Recombinant SV expressing RSV G glycoprotein was prepared by using reverse genetics, and intranasal inoculation of cotton rats elicited RSV-specific antibody and elicited protection from RSV challenge," reported Toru Takimoto and colleagues at St. Jude Children's Hospital in Memphis. "RSV G-recombinant SV is thus a promising live virus vaccine candidate for RSV," wrote
The researchers concluded: "Recombinant SV expressing RSV G glycoprotein was prepared by using reverse ...
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...treatment of illnesses caused by respiratory syncytial virus. "Human respiratory syncytial virus (RSV), a paramyxovirus, is a...into syncytia (RFI-641, a potent respiratory syncytial virus inhibitor, Antimicrobial Agents...
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- Newspaper article from: Proteomics Weekly November 11, 2002 700+ words
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- TaqMan RT-PCR assay sensitive/specific for respiratory syncytial virus...
- Newspaper article from: Science Letter October 19, 2004 700+ words
...and specific for the detection of respiratory syncytial virus. "Respiratory syncytial virus (RSV) is a ubiquitous RNA virus...a quantitative TaqMan RT-PCR for respiratory syncytial virus. J Virol Meth, 2004;120(1...
