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Herpes simplex virus type 2 vaccines under development.
2004 AUG 4 - (NewsRx.com & NewsRx.net) -- Researchers are getting closer to developing effective herpes simplex virus type 2 vaccines.
According to recent research published in the journal Clinical and Diagnostic Laboratory Immunology, "The development of effective prophylactic and therapeutic vaccines against genital herpes has proven problematic. Difficulties are associated with the complexity of the virus life cycle (latency) and our relatively poor understanding of the mechanism of immune control of primary and recurrent disease. The types of effector cells and the mechanisms responsible for their activation and regulation are particularly important."
"Studies from my and other laboratories have shown that recurrent disease is prevented by virus-specific T helper 1 (Th1) cytokines (viz., gamma interferon) and activated innate immunity," said Laure Aurelian at the University of Maryland. "Th2 cytokines (viz., interleukin-10) and regulatory (suppressor) T cells downregulate this immune profile, thereby allowing unimpeded replication of reactivated virus and recurrent disease. Accordingly, an effective therapeutic vaccine must induce Th1 immunity and be defective in Th2 cytokine production, at least IL-10."
"These concepts are consistent with the findings of the most recent clinical trials, which indicate that a herpes simplex virus type 2 (HSV-2) glycoprotein D (gD-2) vaccine formulated with a Th1-inducing adjuvant has prophylactic activity in HSV-2- and HSV-1-seronegative females, ...
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- Oral herpes simplex virus infections.(Disease/Disorder overview)
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...associated with antibodies to herpes simplex virus type 1 (HSV-1). Design...group. ********** Herpes simplex virus type 1 (HSV-1) infection...Blood samples were tested for herpes simplex virus antibody at University of...
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Research findings, 'Herpes simplex virus type 1 infection increases...States report (see also Herpes Simplex Virus Immunology). "Our conclusions...in Archives of Virology (Herpes simplex virus type 1 infection increases...
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- Magazine article from: Phytomedicine: International Journal of Phytotherapy & Phytopharmacology Schuhmacher, A. Reichling, J. Schnitzler, P. July 1, 2003 700+ words
...essential oil of Mentha piperita, against herpes simplex virus was examined. The inhibitory activity against herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2) was tested in vitro...
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- Magazine article from: American Journal of Infectious Diseases Pina, Miguel A. Modrego, Pedro J. Galve, F. January 1, 2006 700+ words
Abstract: Herpes simplex virus type is the most frequent cause...with hepatitis and meningitis by herpes simplex virus. Encephalitis responded to acyclovir...immunological mechanism. Key words: Herpes simplex virus, meningitis, hepatitis, hydrocephalus...
- Studies from University of Saskatchewan, Western College of Veterinary Medicine...
- Newspaper article from: Virus Weekly March 24, 2009 700+ words
...Canada, "The replication of herpes simplex virus (HSV) in epithelial cells...Veterinary Medicine (see also Herpes Simplex Virus Genetics). The researchers...Keywords: Canada, Saskatoon, Herpes Simplex Virus Genetics, Enzyme Research...
- Infections Herpes Simplex Virus Infection.
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...companiesandmarkets.com: Infections Herpes Simplex Virus Infection(C)1994-2009...adds new report: Infections Herpes Simplex Virus Infection Life Science Analytics', Infections Herpes Simplex Virus Infection contains detailed...
Source: HighBeam Research, Herpes simplex virus type 2 vaccines under development.