Kinetics of sCD4 binding to cells expressing HIV-1 envelope glycoprotein. (Research Report)

AUTHORS: D.S. Dimitrov, K. Hillman, J. Manischewitz, R. Blumenthal and H. Golding. U.S. National Cancer Institute, U.S. National Institutes of Health, and Division of Virology, CBER, Food and Drug Administration, Bethesda, Maryland.

According to an abstract submitted by the authors to the joint meeting of the American Society for Biochemistry and Molecular Biology/Biophysical Society, held in Houston, Texas, February 9-13, 1992, "The high -affinity interaction between the HIV-1 envelope glycoprotein and its receptor, CD4, is required for viral entry into cells. We studied the kinetics of binding of the soluble form of CD4 (sCD4) to the virus envelope, expressed …