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During HIV replication within an infected individual, pressure from the immune system may result in selection of virus strains that are more infectious than the original virus.
Northwestern University virologist Steven M. Wolinsky and colleagues used the polymerase chain reaction (PCR) technique to determine the precise genetic makeup of portions of the viral envelope (the V3 loop and the V4-V5 region) in multiple HIV isolates from three mother/child pairs. Wolinsky's team sequenced some 41,500 nucleotide pairs in the course of comparing all of the HIV variants from all of the subjects. Their study appears in the February 28, 1992, …