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Mannosylated cationic liposomes enhance immune response of DNA vaccine.
2004 JUL 14 - (NewsRx.com & NewsRx.net) -- Mannosylated cationic liposomes enhance the immune responses elicited by DNA vaccination.
"The present study investigated the potency of the mannosylated cationic liposomes (Man liposomes) that we have developed in novel DNA vaccine carrier. Ovalbumin (OVA) was selected as a model antigen for vaccination; accordingly, OVA-encoding pDNA (pCMV-OVA) was constructed to evaluate DNA vaccination. The potency of the Man liposome/pCMV-OVA complex was compared with naked pCMV-OVA and that complexed with DC-Chol liposomes," scientists writing in the journal Biochemical and Biophysical Research Communications report.
"In cultured mouse peritoneal macrophages, MHC class I-restricted antigen presentation of the Man liposome/pCMV-OVA complex was significantly higher than that of naked pCMV-OVA and that complexed with DC-Chol liposomes," stated Yoshiyuki Hattori and colleagues at Kyoto University. "After intravenous administration, OVA mRNA expression and MHC class I-restricted antigen presentation on CD11c+ cells and inflammatory cytokines, such as TNF-alpha, IL-12, and IFN-gamma, that can enhance the Th1 response of the Man liposome/pCMV-OVA complex were higher than that of naked pCMV-OVA and that complexed with DC-Chol liposomes."
"Also, the spleen cells from mice immunized by intravenous administration of the Man ...
- Hepatitis C DNA vaccine induces strong DTH response in mice.
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- Mannosylated cationic liposomes enhance immune response of DNA vaccine.
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- Powderject DNA vaccine achieves protective immunity.(Brief Article)
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