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Immune responses to self-antigen after DNA immunization reported.
2004 JUL 14 - (NewsRx.com & NewsRx.net) -- Scientists compare the immune response to a self-antigen after DNA immunization of HLA*A201/H-2Kb and HHD transgenic mice in a recent issue of Vaccine.
"HHD mice which express human HLA-A2 but no mouse class 1, have been shown to have improved cytotoxic lymphocyte (CTL) responses to foreign antigens compared to HLA*A201/Kb transgenic mice. We have previously designed a DNA vaccine to a self-antigen. Vaccination of A2.1/H-2Kb mice with this vaccine resulted in CTL in one-third of the mice, but the frequency of antigen-specific cells was low," researchers in England report.
"An increased frequency was observed in HHD mice, moreover CTL were obtained from all immunized mice," said Judith M. Ramage and colleagues at Nottingham City Hospital. "HHD mice are therefore useful for studying immunization strategies for inducing and maintaining CD8 responses to ...
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Source: HighBeam Research, Immune responses to self-antigen after DNA immunization reported.