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CTLA-4 blockade plus DNA vaccine enhances tumor immunity.
2004 JUL 14 - (NewsRx.com & NewsRx.net) -- A CTLA-4 blockade in combination with xenogeneic DNA vaccines enhances T-cell responses, tumor immunity, and autoimmunity to self-antigens in animal and cellular model systems.
According to recent research published in the journal Vaccine, "Xenogeneic DNA vaccination can elicit tumor immunity through T cell and antibody-dependent effector mechanisms. Blockade of CTLA-4 engagement with B7 expressed on APCs has been shown to enhance T cell-dependent immunity. We investigated whether CTLA-4 blockade could increase T-cell responses and tumor immunity elicited by DNA vaccines."
"CTLA-4 blockade enhanced B 16 tumor rejection in mice immunized against the melanoma differentiation antigens tyrosinase-related protein 2 and gp100, and this effect was stronger when anti-CTLA-4 was administered with booster vaccinations," reported Polly D. Gregor at the Memorial Sloan-Kettering Cancer Center and collaborators throughout the U.S. "CTLA-4 blockade also increased the T-cell responses to prostate-specific membrane antigen (PSMA) when given with the second or third vaccination."
The researchers concluded, ...
- CTLA-4 blockade plus DNA vaccine enhances tumor immunity.
- Newspaper article from: Biotech Week July 14, 2004 700+ words
...vaccination can elicit tumor immunity through T cell and...mechanisms. Blockade of CTLA-4 engagement with...investigated whether CTLA-4 blockade could...cell responses and tumor immunity elicited by DNA vaccines." "CTLA-4 blockade enhanced...
- CTLA-4 antibody blockade increases tumor immunity in cancer patients.
- Newspaper article from: Immunotherapy Weekly June 18, 2003 700+ words
...net) -- A CTLA-4 antibody...blockade increased tumor immunity in some previously...antigen 4 (CTLA-4) further...potency of tumor immunity," said F...suggest that CTLA-4 antibody...blockade increases tumor immunity in some previously...
- RNA aptamers can bind and inhibit CTLA-4, increasing antitumor activity.
- Newspaper article from: Cancer Vaccine Week January 19, 2004 700+ words
...RNA aptamers that bind CTLA-4 with high affinity...These aptamers inhibit CTLA-4 function in vitro and enhance tumor immunity in mice," wrote S...aptamers that inhibit CTLA-4 and enhance tumor immunity. Cancer Res, 2003...
- CTLA-4 blockade enhances effect of poxvirus vaccine targeting p53 in tumor...
- Newspaper article from: Cancer Vaccine Week May 5, 2003 700+ words
...amp; NewsRx.net) -- A CTLA-4 blockade enhanced the therapeutic...treated 6 days later with anti-CTLA-4 antibodies (9H10) and...regression along with lasting tumor immunity. In vivo antibody depletion...the Journal of Immunology (CTLA-4 blockade enhances the therapeutic...
- Stem cell CTLA-4 may be therapeutic target.
- Newspaper article from: Immunotherapy Weekly February 26, 2003 700+ words
...cytotoxic T-lymphocyte antigen-4 (CTLA-4) molecule in human normal and neoplastic...analysis carried out with a panel of anti-CTLA-4 human single-chain fragment of variable domain (scFv) antibodies revealed that CTLA-4 was not expressed on the surface...
- Stem cell CTLA-4 may be therapeutic target.(Brief Article)
- Magazine article from: Stem Cell Week February 24, 2003 700+ words
...cytotoxic T-lymphocyte antigen-4 (CTLA-4) molecule in human normal and neoplastic...analysis carried out with a panel of anti-CTLA-4 human single-chain fragment of variable domain (scFv) antibodies revealed that CTLA-4 was not expressed on the surface...
- Stem cell CTLA-4 may be therapeutic target.(cytotoxic T-lymphocyte antigen-4 in...
- Newspaper article from: Cancer Weekly February 25, 2003 700+ words
...cytotoxic T-lymphocyte antigen-4 (CTLA-4) molecule in human normal and neoplastic...analysis carried out with a panel of anti-CTLA-4 human single-chain fragment of variable domain (scFv) antibodies revealed that CTLA-4 was not expressed on the surface...
- Tyrosine-mediated inhibitory signals contribute to CTLA-4 function.
- Newspaper article from: Blood Weekly June 3, 2004 700+ words
...Tyrosine-mediated inhibitory signals contribute to CTLA-4 function. "The ability of CTLA-4 to inhibit T cell activation may be either...critical tyrosine at position 201 (Y201) within the CTLA-4 cytoplasmic domain. By binding to the clathrin...
