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Adenovirus encoding HCA661 targets hepatoma cells.
2004 JUL 14 - (NewsRx.com & NewsRx.net) -- Transduction of dendritic cells with recombinant adenovirus encoding HCA661 activates autologous cytotoxic T lymphocytes to target hepatoma cells.
According to recent research from China, "Transduction of recombinant adenovirus into dendritic cells (DCs) is a promising new tool for cancer vaccine development. Here, we report that an adenovirus vector carrying hepatocellular carcinoma (HCC) antigen HCA661 and infected into DCs generates T-cell immunity against hepatoma cells. HCA661 is a novel cancer/testis (CT) antigen screened by SEREX from sera of an HCC patient. We constructed a recombinant adenovirus expressing the full-length cDNA of HCA661 gene and then transduced immature DCs, which had been generated with GM-CSF and IL-4 from peripheral blood mononuclear cell of HLA-A2+ healthy donors."
"The resulting adenovirus-transduced DCs differentiated in the presence of monocyte-conditioned medium and poly [I]:poly [C], expressing the surface markers of mature DCs, including CD83, CD80, CD86, and HLA-DR," stated R. C.-F. Chan and collaborators at the Hong Kong University of Science and Technology and Peking University. "After maturation, the transduced DCs transcribed HCA661 mRNA and were able to prime the naive T cells to become cytotoxic T lymphocytes (CTLs). Intracellular flow cytometry and enzyme-linked immunospot assay ...
- Adenovirus encoding HCA661 targets hepatoma cells.
- Newspaper article from: Drug Week July 16, 2004 700+ words
...collaborators at the Hong Kong University of Science...activate T cells to target hepatoma cells," concluded the scientists...lymphocytes to target hepatoma cells. Brit J Cancer, 2004...Department of Biology, The Hong Kong University of Science...
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- Newspaper article from: Obesity, Fitness & Wellness Week August 14, 2004 700+ words
...protein modulates Wnt/beta-catenin in hepatoma cells. According to recent research published...of Wnt/beta-catenin signaling in hepatoma cells has not been established." "We found...ectopic expression of Wnt-1 in some hepatoma cells, such as Hep3B and PLC/PRF/5 cells...
- Infection Impacts Differentiated Hepatoma Cells.(dengue virus)
- Newspaper article from: Hepatitis Weekly May 1, 2000 700+ words
...and severely infects differentiated hepatoma cells. Y.L. Lin and associates at the...replication rate in the four infected hepatoma cells," the researchers said. In addition...cytopathic effects in differentiated hepatoma cells. Factors related to differentiation...
- Effects of ascorbic acid and sodium selenite on growth and redifferentiation in...
- Magazine article from: Alternative Medicine Review Zheng, QS Zheng, RL August 1, 2002 700+ words
...growth rate and mitotic index of human hepatoma cells BEL-7402 decreased remarkably. The...3%. These results indicated that hepatoma cells had been successfully induced to redifferentiation...may induce the redifferentiation of hepatoma cells and inhibit cell growth by virtue of...
- Melatonin inhibits serum deprivation-induced apoptosis in rat hepatoma cells.
- Newspaper article from: Proteomics Weekly October 27, 2003 700+ words
...deprivation-induced apoptosis in rat hepatoma cells. According to a study from Canada...following serum deprivation of 5123tc hepatoma cells," reported Siyaram Pandey and colleagues...deprivation-induced apoptosis in rat hepatoma cells; inhibition of cell death by melatonin...
- Radiation causes cytotoxic conditioning of the culture medium of hepatoma cells.
- Newspaper article from: Clinical Oncology Week May 5, 2003 700+ words
...conditioning of the culture medium of hepatoma cells. According to published research...Netherlands, "Cultured H35 hepatoma cells release a cytotoxic factor...of the culture medium of H35 hepatoma cells. Br J Cancer, 2003;88...
- Hepatoma cells support replication of wild-type and mutant GB virus B replicons.
- Newspaper article from: Drug Week December 26, 2003 700+ words
2003 DEC 26 - (NewsRx.com & NewsRx.net) -- Hepatoma cells support replication of wild-type and mutant GB virus B...published their study in Journal of Virology (Hep3B human hepatoma cells support replication of the wild-type and a 5'-end deletion...
- Indinavir suppresses glycogen synthesis in HepG2 hepatoma cells.
- Newspaper article from: AIDS Weekly May 5, 2003 700+ words
...inhibitor indinavir suppresses glycogen synthesis in HepG2 hepatoma cells. Protease inhibitor therapy "is associated with insulin...inhibitor indinavir impairs glycogen synthesis in HepG2 hepatoma cells. Exp Clin Endocrinol Diabetes, 2003;111(1):16...
