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Genetic immunization effective against anthrax.
2004 JUL 14 - (NewsRx.com & NewsRx.net) -- Genetic immunization is effective against anthrax.
According to recent research from the United States, "The objective of this study was to determine whether a DNA prime-protein boost immunization against the Bacillus anthracis protective antigen (PA) and lethal factor (LF) antigens could induce a protective immune response against significant aerosol challenge in the rabbit model. Rabbits were vaccinated with different regimens of DNA vaccines and aerosol challenged with B. anthracis spores, Ames strain, with an average dose of 50 LD[subscript]50s with a range from 18 to 169 LD[subscript]50s."
"Of the five vaccinated rabbits that survived, two were immunized intramuscularly (i.m.) with DNA followed with a protein boost and three were immunized subcutaneous (s.q.) with recombinant protein," reported Darrell Galloway and collaborators at the U.S. Naval Medical Research Center, Ohio State University, and the Batelle Memorial Institute. "A major factor predicting survival was the ability of the animal to mount a lasting antibody response to PA. Rabbit sera were collected prior to and following aerosol challenge and titrated for ...
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- Newspaper article from: Vaccine Weekly February 12, 2003 700+ words
...Oxon, UK. The information in this article comes under the major subject areas of Leishmaniasis, DNA Vaccine, Vaccine Development, and Vaccine Efficacy. This article was prepared by Vaccine Weekly editors from staff and other reports.
Source: HighBeam Research, Genetic immunization effective against anthrax.