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Minimalistic expression constructs are vectors for DNA vaccines.
2004 JUL 14 - (NewsRx.com & NewsRx.net) -- Minimalistic expression constructs show promise as vectors for DNA vaccines.
According to published research from Spain, "The low efficacy obtained in large animals makes plasmid-based DNA vaccines commercially unviable. Another concern is the presence of antibiotic resistance markers on virtually all conventional plasmids. Here we describe the use of minimalistic, immunogenically defined gene expression (MIDGE) vectors for DNA vaccination."
"MIDGE are linear, covalently-closed vectors containing all the essential information for gene expression and none of the non-essential and potentially dangerous plasmid backbone sequences," said S. Moreno and colleagues at Mologen Molecular Medicines SL. "MIDGE vectors can also be chemically modified on both ends at defined positions allowing targeting of the DNA to specific cell types or cellular compartments. Immunization of mice with simple and end-modified MIDGE ...
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Source: HighBeam Research, Minimalistic expression constructs are vectors for DNA vaccines.