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Nanoparticles enhance immunogenicity of tuberculosis DNA vaccine.
2004 JUL 14 - (NewsRx.com & NewsRx.net) -- Pulmonary delivery of chitosan-DNA nanoparticles enhances the immunogenicity of a DNA vaccine encoding HLA-A*0201-restricted T-cell epitopes of Mycobacterium tuberculosis.
"In this study, we used an HLA-A2 transgenic mouse model to investigate the effects of pulmonary delivery of a new DNA plasmid encoding eight HLA-A*0201-restricted T-cell epitopes from Mycobacterium tuberculosis formulated in chitosan nanoparticles. It was shown that the chitosan-DNA formulation was able to induce the maturation of dendritic cells (DCs) while chitosan solution alone could not, indicating the DNA was released from the particles and able to stimulate DCs," researchers in Netherlands report.
"Pulmonary administration of the DNA plasmid incorporated in chitosan nanoparticles was shown to induce increased levels of IFN-gamma secretion compared to pulmonary delivery of plasmid in solution or the more frequently used intramuscular immunization route," stated Maytal Bivas-Benita and collaborators at the Leiden/Amsterdam Center for Drug Research and Leiden University. "These results indicate that pulmonary delivery of DNA vaccines against tuberculosis may provide an advantageous delivery ...
- Nanoparticles enhance immunogenicity of tuberculosis DNA vaccine.
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Source: HighBeam Research, Nanoparticles enhance immunogenicity of tuberculosis DNA vaccine.