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Tobacco cells produce antibodies to hepatitis B virus surface antigen.
2004 JUL 14 - (NewsRx.com & NewsRx.net) -- Transgenic tobacco cells can produce human monoclonal antibodies to hepatitis B virus surface antigen.
"The recombinant human monoclonal antibody (MAb) against hepatitis B virus (HBV) surface antigen (HBsAg) was expressed in tobacco suspension cultures. The parental CL4MAb was produced by the Epstein-Barr virus (EBV)-transformed human cell line TAPC301-CL4. The CL4MAb cDNA was introduced into tobacco suspension cells by Agrobacterium-mediated transformation," scientists in Japan report.
"The monoclonal antibodies (MAbs), B294 and B303, which were derived from CL4 and subsequently produced in plant cells were selected for study," said Akira Yano at the National Institute of Public Health in Tokyo and colleagues at Tokai University. "After purification on protein A columns, B294 and B303 MAbs had anti-HBs relative affinity constants similar to the parental CL4MAb. B303 MAb interacted with cell surface HBsAgs and showed complement-dependent cytotoxicity in a manner that was similar to anti-HBs human immunoglobulins ...
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- Tobacco cells produce antibodies to hepatitis B virus surface antigen.
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Source: HighBeam Research, Tobacco cells produce antibodies to hepatitis B virus surface antigen.