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Patients on Cox-2 therapy who take aspirin possibly negate benefits.
2004 JUL 5 - (NewsRx.com & NewsRx.net) -- A new study has found that more than half of patients taking Cox-2 anti-inflammatory drugs on a long-term basis were also taking aspirin therapy for its cardio-protective benefit.
Previously published clinical research has shown that using aspirin along with Cox-2 therapies can negate the gastrointestinal (GI) benefit of using Cox-2's, one of the primary reasons for using these more costly medications.
Researchers at pharmacy benefit manager Express Scripts examined aspirin and other over-the-counter pain reliever use among Cox-2 users from a large employer group. Their findings were reported in a study published in the Archives of Internal Medicine.
In addition to the high rate of aspirin use, half of the aspirin users were taking daily doses of 325 mg or more, which is considered higher than necessary for the primary prevention of cardiovascular disease and stroke.
Aspirin use has been shown to significantly increase the risk of bleeding in the GI tract, even at low doses, and guidelines state that patients who require aspirin therapy for cardio-protection should use the lowest dose possible.
"These findings have important implications for patient safety and cost," said Emily Cox, PhD, lead author of the study. "For patients ...
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- Newspaper article from: Drug Week July 9, 2004 700+ words
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- Magazine article from: OB GYN News Finn, Robert January 15, 2003 700+ words
...have been prescribed COX-2 inhibitors and...taking low doses of aspirin for its cardioprotective...increase in response to aspirin's inhibition of COX-1. Selective COX-2 inhibitors could...in the presence of aspirin, but nor in its absence...
