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Actos shows sustained efficacy over 2-year period.
2004 JUL 5 - (NewsRx.com & NewsRx.net) -- Long-term studies using the oral antidiabetic drug Actos (pioglitazone HCl) alone, and in combination with other oral antidiabetic medications, found that it provided sustained improvements in glycemic control, insulin sensitivity and key lipid parameters over a 104-week period.
The findings were presented at the American Diabetes Association's (ADA) 64th Annual Scientific Sessions.
"Given the clinical challenges of managing diabetes patients over time, and the fact that patients are living longer with diabetes, the data being presented on Actos help physicians better understand the drug's effectiveness over an extended period," said Mehmood Khan, MD, FACE, senior vice president for medical and scientific affairs, Takeda Pharmaceuticals. "Physicians are mindful that sustained improvements in A1C are essential to the long-term health of patients with type 2 diabetes."
These studies, which were all conducted over a 2-year period, compared the effects of Actos either alone or in combination with two other commonly used oral antidiabetic medications: a sulfonylurea (gliclazide) and metformin.
In one study of 1269 patients with type 2 diabetes, four different regimens were evaluated over 2 years of treatment: Actos (15-45 mg/day) or metformin (850-2550 mg/day), added to existing sulfonylurea therapy (gliclazide, 80-320 mg/day); and, using the same dosages, Actos or a sulfonylurea (gliclazide) added to existing metformin therapy.
Results showed that, whether combined with metformin or sulfonylurea, the addition of Actos produced the greatest reduction in fasting insulin; decreases were sustained over the 2 years. At 104 weeks, changes in serum insulin levels from baseline for the two arms of the study were:
1) Actos added to metformin: decrease of 2.6 microIU/mL; gliclazide added to metformin: increase of 1.9 microIU/mL.
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Source: HighBeam Research, Actos shows sustained efficacy over 2-year period.