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Novel M. tuberculosis gene products to detect TB identified.
2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Scientists have identified novel RD1- and RD2-encoded Mycobacterium tuberculosis gene products for the specific detection of human tuberculosis infection.
According to a study from England, "The tuberculin skin test for diagnosing Mycobacterium tuberculosis infection suffers from antigenic cross-reactivity of purified protein derivative with BCG, resulting in poor specificity in BCG-vaccinated populations. Comparative genomics has identified several genetic regions in M. tuberculosis and M. bovis that are deleted in M. bovis BCG. Proteins encoded in these regions will form the basis of new specific T-cell-based blood tests that do not cross-react with BCG, but only two, early secretory antigen target 6 and culture filtrate protein 10, have been studied in detail in humans."
"We investigated four novel gene products, encoded by RD2 (Rv1989c) and RD1 (Rv3873, Rv3878, and Rv3879c), which are absent from most or all of the vaccine strains of BCG, respectively," reported Xiao-Qing Liu at the University of Oxford and collaborators in England. "Sixty-seven overlapping peptides were tested in ex vivo gamma interferon enzyme-linked immunospot assays in 49 patients with culture-confirmed tuberculosis and 38 healthy BCG-vaccinated donors."
"Forty-five percent (95% confidence interval [CI], 31 to 57%) and 53% (95% CI, 39 to 67%) of the tuberculosis patients responded to Rv3879c and Rv3873, respectively, identifying these proteins as major M. tuberculosis T-cell antigens in humans, while 35 and 25% of the patients responded to Rv3878 and Rv1989c, ...
- Novel M. tuberculosis gene products to detect TB identified.
- Newspaper article from: Tuberculosis Week July 5, 2004 700+ words
...encoded Mycobacterium tuberculosis gene products for the specific detection...investigated four novel gene products, encoded by RD2 (Rv1989c...encoded Mycobacterium tuberculosis gene products for specific detection of...
- Tuberculosis gene may explain dormancy. (research indicates that SigF gene...
- Magazine article from: Science News April 20, 1996 700+ words
The tuberculosis bacterium is nothing if not an artful dodger. Over the years, it has proved itself capable of eluding almost every trap mankind has laid. Now, researchers have gained an important insight into an ancient conundrum-how the tuberculosis microbe manages to remain dormant in the lungs
- Scientists find tuberculosis gene.
- News wire article from: UPI NewsTrack August 17, 2005 700+ words
MONTREAL, Aug. 17 (UPI) -- Scientists at the McGill University Health Center in Montreal have found a gene that controls the speed at which patients develop tuberculosis. The researchers say their study marks the first time such a gene has been discovered for TB and provides a new view of the
- Suppression of new oncogene-induced transformation by the adenovirus-5 E1A gene...
- Newspaper article from: Cancer Weekly Yu, Dihua Hung, Mien-Chie February 4, 1991 700+ words
...cancer patients. The adenovirus E1A gene products are pleiotropic transcription regulators...can be strongly repressed by the E1A gene products. Both the 13S and 12S products of...transcriptional repression of neu by the E1A gene products can inhibit the transforming ability...
- Unique genes or gene products profile hepatocellular carcinomas.
- Newspaper article from: Drug Week July 2, 2004 700+ words
...NewsRx.com & NewsRx.net) -- Unique genes or gene products profile hepatocellular carcinomas. According to a study...Department of Pathology stated. "These unique genes or gene products associated with malignant transformation and recurrent or...
- Showing by glowing. (tagging gene products)
- Magazine article from: Science News September 6, 1986 700+ words
Showing by glowing Meanwhile, back at the genetic level of development: Researchers have found a way to tag gene products with light, making it possible to watch as genes on chromosomes in living organisms are turned on and off. The researchers...
- Effect of retinoic acid on the expression of tumor suppressor gene products in...
- Newspaper article from: Cancer Weekly Maxwell, Steve A. Mukhopadhhyay, Tapas Cavender, Adriana Johnson, Marjorie Roth, Jack A. January 28, 1991 700+ words
...whereas the H226b and H322a cell lines exhibit little or no response. The expression of the retinoblastoma (Rb) and p53 gene products were analyzed to determine if changes in tumor-suppressor proteins might correlate with the retinoic acid-induced growth...
- Acacia Research Subsidiary Awarded Second Government Contract; Department of...
- Press release article from: Business Wire July 20, 1999 700+ words
...is to use CombiMatrix's proprietary biochip technology to develop microarrays of affinity probes for the analysis of gene products. This work is expected to speed up the pace at which researchers in the pharmaceutical industry can identify new drug discovery...
- Nestle Answers to Questioning on Modified Gene Products.
- News wire article from: Asia Africa Intelligence Wire December 9, 2002 700+ words
(From SinoCast China Business Daily News) CHINA, December 10, SinoCast -- A media from Shanghai lately unveiled in its article that 6 of Nestle's products contain unknown genes. Nestle (China) Co., Ltd. responded to News Express on December 3 and 4, refuting the comment of this media. Nestle claims
- Green tea antioxidant lowers activated stellate cells, gene products.
- Newspaper article from: Gastroenterology Week March 3, 2003 700+ words
2003 MAR 3 - (NewsRx.com & NewsRx.net) -- According to recent research from the United States, "Activated hepatic stellate cells (HSC) are the primary source of excessive production of extracellular matrix during liver fibrogenesis. Although the underlying mechanisms remain incompletely
Source: HighBeam Research, Novel M. tuberculosis gene products to detect TB identified.