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Methoxymycolic acid loss by M. bovis does not affect BCG virulence.
2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Loss of methoxymycolic acid production by Mycobacterium bovis does not affect the virulence of BCG vaccine strains.
"BCG vaccines are a family of closely related daughter strains of an attenuated isolate of Mycobacterium bovis derived by in vitro passage from 1908 to 1921. During subsequent laboratory propagation of the vaccine strain until its lyophilization in 1961, BCG Pasteur underwent at least seven further genomic mutations. The impact of these mutations on the properties of the vaccine is currently unknown," scientists writing in the journal Infection and Immunity report.
"One mutation, a glycine-to-aspartic acid substitution in the mmaA3 gene, occurred between 1927 and 1931 and impairs methoxymycolic acid synthesis in BCG strains obtained from the Pasteur Institute after this period," said Adam Belley and collaborators at McGill University and the University of Toronto in Canada and the University of Washington in the United States. "Mycolic acids of the cell wall are classified into three functional groups (alpha-, methoxy-, and ketomycolic acids), and together these lipids form a highly specialized permeability barrier around the bacterium."
"To explore the impact of methoxymycolic acid production by BCG strains, we complemented the functional gene of mmaA3 into BCG Denmark and tested a number ...
- Point Mutation in mma3 Gene is Responsible for Impaired Methoxymycolic Acid...
- Newspaper article from: Vaccine Weekly August 2, 2000 700+ words
...Researchers in Canada have discovered why methoxymycolic acid production in Mycobacterium bovis strains of bacillus...the mma3 gene is responsible for impaired methoxymycolic acid production in Mycobacterium bovis BCG strains obtained...
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...Researchers in Canada have discovered why methoxymycolic acid production in Mycobacterium bovis strains of bacillus...the mma3 gene is responsible for impaired methoxymycolic acid production in Mycobacterium bovis BCG strains obtained...
- Methoxymycolic acid loss by M. bovis does not affect BCG virulence.
- Newspaper article from: Health & Medicine Week July 5, 2004 700+ words
...net) -- Loss of methoxymycolic acid production by Mycobacterium bovis...explore the impact of methoxymycolic acid production by BCG strains, we...demonstrate that the loss of methoxymycolic acid production did not apparently...
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