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Shigella flexneri mutant shows no attenuation of virulence.
2004 JUL 7 - (NewsRx.com & NewsRx.net) -- A DNA adenine methylase mutant of Shigella flexneri shows no significant attenuation of virulence.
"Mutants of Salmonella defective in DNA adenine methylase (dam) have been reported to be attenuated for virulence and to provide protective immunity when used as vaccine strains. To determine whether these observations could be extended to Shigella, a dam mutant of Shigella flexneri 2a was characterized and examined for the role of dam in pathogenesis. The Shigella dam mutant showed some unique characteristics; however, it retained virulence in vivo as well as in vitro," scientists in the United States report.
"The mutant invaded cultured L2 monolayer cells as efficiently as the wild-type parent, but its intracellular growth was suppressed up to 7 hours post-invasion," said Yasuko Honma and colleagues at the Uniformed Services University of the Health Sciences. "Furthermore, the invading dam mutant formed smaller plaques in cell monolayers compared to the parent strain. However, the mutant produced keratoconjunctivitis in the Sereny test in guinea pigs only slightly more slowly than the wild-type. While the effect of the dam mutation on virulence was modest, the rate of spontaneous mutation in the dam mutant was 1000-fold greater ...
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Source: HighBeam Research, Shigella flexneri mutant shows no attenuation of virulence.