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Colloidal bacterial extract elicits specific immune responses.
2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Intranasal immunization with a colloid-formulated bacterial extract induces an acute inflammatory response in the lungs and elicits specific immune responses.
"Nonspecific stimulation of lung defenses by repeated oral administration of immunomodulators, such as bacterial extracts, has shown potential for the prevention of respiratory tract infections. Here, we show that intranasal (i.n.) immunization with a bacterial extract formulated as a colloid induces an acute inflammatory response in the lungs characterized by increased production of CCL and CXCL chemokines and a major influx of dendritic cells (DCs) and neutrophils, with a higher proportion of DCs showing an activated phenotype (high CD80/CD86 expression)," researchers in Uruguay report.
"Cytokine levels measured in bronchoalveolar-lavage samples showed a small increase in the production of tumor necrosis factor alpha and similar levels of the other cytokines measured (interleukin 10 [IL-10], IL-12, and gamma interferon [IFN-gamma]) in immunized mice compared with control mice," said A. Rial and collaborators at the Instituto de Higiene in Uruguay and the University of Sao Paulo in Brazil. "However, the recall response of primed animals after antigenic challenge induced increased expression of IL-12 and IFN-gamma mRNAs in lung homogenates."
"Overall, all these effects were not due to the lipopolysaccharide content in the bacterial extract," stated the scientists. "Furthermore, we found that three i.n. doses administered 2 to 3 weeks apart were enough to elicit long-lasting specific serum immunoglobulin G (IgG) ...
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Source: HighBeam Research, Colloidal bacterial extract elicits specific immune responses.