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Mutants of lactic acid bacteria enhance mucosal delivery of antigen.
2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Cell wall mutants of lactic acid bacteria enhance the mucosal delivery of antigen.
According to recent research from France, "The potential of recombinant lactic acid bacteria (LAB) to deliver heterologous antigens to the immune system and to induce protective immunity has been best demonstrated by using the C subunit of tetanus toxin (TTFC) as a model antigen. Two types of LAB carriers have mainly been used, Lactobacillus plantarum and Lactococcus lactis, which differ substantially in their abilities to resist passage through the stomach and to persist in the mouse gastrointestinal tract."
"Here we analyzed the effect of a deficiency in alanine racemase, an enzyme that participates in cell wall synthesis, in each of these bacterial carriers," said Corinne Grangette at the Institut Pasteur de Lille in France and collaborators in France and Belgium. "Recombinant wild-type and mutant strains of L. plantarum NCIMB8826 and L. lactis MG1363 producing TTFC intracellularly were constructed and used in mouse immunization experiments. Remarkably, we observed that the two cell wall mutant strains were far more immunogenic than their wild-type counterparts when the intragastric route was used."
"However, intestinal TTFC-specific immunoglobulin A was induced only after immunization with the recombinant L. ...
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Source: HighBeam Research, Mutants of lactic acid bacteria enhance mucosal delivery of antigen.