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Lipopolysaccharide of Neisseria meningitidis examined.
2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Researchers distinguish the structural determinants of 'toxicity' and 'adjuvanticity' in the lipopolysacchracide of Neisseria meningitidis in a recent issue of the Journal of Endotoxin Research.
"The use of lipopolysaccharide (LPS) as an adjuvant is limited by its high endotoxic activity. In particular, the fatty-acyl pattern of the lipid A part of LPS has been demonstrated to determine its biological activity. By genetic modification of the lipid A biosynthesis pathway in Neisseria meningitidis, a panel of recombinant strains with specific alterations in the lipid A acylation pattern, as well as a strain completely lacking LPS were isolated," scientists in the Netherlands report.
"Whereas all variations in the fatty-acyl pattern resulted in reduced endotoxic activity, as measured by TNF-alpha induction in the human macrophage cell line MM6, the adjuvant activity of the modified LPS was, in most cases, barely affected," stated Liana Steeghs and colleagues at the University of Utrecht. "The in vivo adjuvant properties of N. meningitidis wild-type and mutant LPS was found to correlate with induction of co-stimulatory molecules, in particular CD80 and CD40, and with IL-12 production by LPS-stimulated bone marrow-derived BALB/c dendritic cells in vitro."
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Source: HighBeam Research, Lipopolysaccharide of Neisseria meningitidis examined.