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Leukocyte antigen alleles affect antibodies to Plasmodium antigen.
2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Human leukocyte antigen class II alleles influence levels of antibodies to the Plasmodium falciparum asexual-stage apical membrane antigen 1 but not to merozoite surface antigen 2 and merozoite surface protein 1.
"The apical membrane antigen 1 (AMA1), merozoite surface antigen 2 (MSA2), and merozoite surface protein 1 (MSP1) are asexual-stage proteins currently being evaluated for inclusion in a vaccine for Plasmodium falciparum. Accordingly, it is important to understand factors that control antibody responses to these antigens. Antibody levels in plasma from residents of Etoa, Cameroon, between the ages of 5 and 70 years, were determined using recombinant AMA1, MSA2, and the N-terminal region of MSP1 (MSP1-190L)," scientists writing in the journal Infection and Immunity report.
"In addition, antibody responses to four variants of the C-terminal region of MSP1 (MSP1[subscript]19) were assessed," said Armead H. Johnson at Georgetown University in the U.S. and collaborators throughout the world. "Results showed that all individuals produced antibodies to AMA1, MSA2, and MSP1-190L; however, a proportion of individuals never produced antibodies to the MSP1[subscript]19 variants, although the percentage of nonresponders decreased with age. The influence of age and human leukocyte antigen (HLA)-DRB1/DQB1 alleles on antibody levels was evaluated using two-way analysis of variance. Age was correlated with levels of antibodies to AMA1 and MSP1[subscript]19 but not with levels of antibodies to MSA2 and MSP1-190L."
"No association was found between a single HLA allele and levels of antibodies to MSA2, MSP1-190L, or any of the MSP1[subscript]19 variants," reported the ...
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- Leukocyte antigen alleles affect antibodies to Plasmodium antigen.
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Source: HighBeam Research, Leukocyte antigen alleles affect antibodies to Plasmodium antigen.