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Immunity and immunosuppression in visceral leishmaniasis reviewed.
2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Scientists review immunity and immunosuppression in experimental visceral leishmaniasis in a recent issue of the Brazilian Journal of Medical and Biological Research.
"Leishmaniasis is a disease caused by protozoa of the genus Leishmania, and visceral leishmaniasis is a form in which the inner organs are affected. Since knowledge about immunity in experimental visceral leishmaniasis is poor, we present here a review on immunity and immunosuppression in experimental visceral leishmaniasis in mouse and hamster models. We show the complexity of the mechanisms involved and differences when compared with the cutaneous form of leishmaniasis," researchers in Brazil report.
"Resistance in visceral leishmaniasis involves both CD4+ and CD8+ T cells, and interleukin (IL)-2, interferon (IFN)-gamma, and IL-12, the latter in a mechanism independent of IFN-gamma and linked to transforming growth factor (TGF)-beta production," said H. Goto and J. A. L. Lindoso at the University of Sao Paulo. "Susceptibility involves IL-10 but not IL-4, and B cells. In immune animals, upon re-infection, the elements involved in resistance are different, i.e., CD8+ T cells and IL-2. Since one of the immunopathological consequences of active visceral leishmaniasis in humans is suppression of T-cell responses, many studies have been conducted using experimental models."
"Immunosuppression is mainly Leishmania antigen specific, and T cells, Th2 cells, and adherent antigen-presenting cells have been shown to be involved," stated the ...
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Source: HighBeam Research, Immunity and immunosuppression in visceral leishmaniasis reviewed.