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Leishmania amastigotes induce transcription factor in macrophages.
2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Leishmania major amastigotes induce p50/c-Rel NF-kappa B transcription factor in human macrophages.
"Invasion of a host by pathogens is frequently associated with activation of nuclear factor kappa B (NF-kappaB), which is implicated in various aspects of immune function required for resistance to infection. However, pathogens may also subdue these mechanisms to secure their survival. Here we describe the effect of Leishmania major infection on NF-kappaB transcription factor activation in both promonocytic human cell line U937 and fresh human monocytes," scientists in Tunisia report.
"Infection by L. major amastigotes blocked nuclear translocation of a phorbol-12 myristate-13 acetate (PMA)-induced p50/p65 NF-kappaB complex in PMA-treated differentiated U937 cells and triggered expression of p50- and c-Rel-containing complexes in both U937 cells and fresh human monocytes," stated Lamia Guizani-Tabbane and colleagues at the Institut Pasteur de Tunis. "These p50/c-Rel complexes, triggered by direct cell-parasite interactions, were detectable within 30 minutes after the interaction and were transcriptionally active."
"The NF-kappaB inhibitor caffeic acid phenethyl ester inhibited production of both tumor necrosis factor alpha and interleukin-10 (IL-10) induced by Leishmania amastigotes in differentiated U937 cells," reported the ...
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Source: HighBeam Research, Leishmania amastigotes induce transcription factor in macrophages.