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OX40L needed for alloantibody production after alloimmunizations.
2004 JUL 7 - (NewsRx.com & NewsRx.net) -- OX40L plays an essential role on B cells in persistent alloantibody production following repeated alloimmunizations.
"OX40/OX40 ligand (OX40L) interactions are implicated in costimulation for both CD4+ T and B cells in a bidirectional manner. To determine the role of OX40/OX40L interactions in recipient antidonor responses after multiple allogeneic transfusions, we examined alloreactive cytotoxic T lymphocyte (allo-CTL) activity and alloantibody production in repeatedly alloimmunized OX40L-deficient mice," scientists in Japan report.
"After the fifth alloimmunization, whereas OX40L-deficient mice showed allo-CTL activity with levels comparable to those of wild-type mice, alloantibody production in OX40L-deficient mice was significantly reduced, accompanied by fewer memory B and CD4C T cells with reduced function," stated Hiroshi Kato and collaborators at Dokkyo University and Tohoku University. "Furthermore, nu/nu mice that received OX40L-deficient T cells still exhibited impaired alloantibody production with fewer memory CD4C T and B cells. In contrast, RAG-2-deficient mice that received both wild-type T cells and OX40L-deficient B cells produced ...
- OX40L needed for alloantibody production after alloimmunizations.
- Newspaper article from: Immunotherapy Weekly July 7, 2004 700+ words
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