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Normalizing hemoglobin aids hemodialysis patients.
2004 JUL 7 - (NewsRx.com & NewsRx.net) -- Normalizing the hemoglobin concentration in hemodialysis patients who receive recombinant human erythropoietin.
"Partial correction of anemia by erythropoietin improves hemodialysis (HD)-associated immunosuppression. It is not known whether hemoglobin normalization improves immune status further. The authors prospectively compared the immune function of HD patients with congestive heart failure or ischemic heart disease on erythropoietin therapy randomized to normal versus anemic blood hemoglobin concentration," researchers in the United States report.
"HD patients were randomized into a normal hemoglobin group (n=17, target hemoglobin of 14[+ or -]1 g/dL) or an anemic hemoglobin group (n=18, target hemoglobin 10[+ or -]1 g/dL)," said Renato M. B. Roman and collaborators at the University of Virginia and Amgen, Inc. "Delayed-type hypersensitivity, CD4 and CD8 counts, anti-tetanus toxoid antibody levels, erythrocyte complement receptor 1 expression, and lymphocyte proliferative responsiveness were measured. The observation period was 1 year, and the trial was open label. Target hemoglobin was achieved and maintained in both groups."
"Significantly improved cutaneous reactivity was seen in the normal hemoglobin group (p=0.003)," reported the investigators. "The prevalence of anergy decreased in the normal hemoglobin group (from 60 to 20%) but increased in the anemic hemoglobin group (from 57 to 86%). The anemic hemoglobin group had higher CD8 counts compared with baseline (p=0.0001) and compared with the normal hemoglobin group (p=0.038). Both groups had significant ...
- Human Gamma-Globin Expression In Mice Improves Normal Hemoglobin Levels.
- Newspaper article from: Gene Therapy Weekly June 7, 2001 700+ words
...transfusions. Gene therapy to restore normal hemoglobin synthesis is an attractive solution...resulted in a marked increase in normal hemoglobin levels. They also noted that the...greater than 2 g/dL increase in normal hemoglobin. In these mice, reticulocytosis...
- 'Normal' Hemoglobin Decline in ICU Patients.(Clinical report)
- Newspaper article from: Critical Care Alert September 1, 2003 700+ words
Normal Hemoglobin Decline in ICU Patients Abstract...patients to have a more rapid rate of normal hemoglobin decline, but this was the case...further reduce this component of the normal hemoglobin decline during a patients stay...
- Erythropoietin Use in Breast Cancer Patients with Normal Hemoglobin Levels May...
- Newspaper article from: Clinical Oncology Alert November 1, 2005 700+ words
...Use in Breast Cancer Patients with Normal Hemoglobin Levels May Lead to Increased Mortality...Leyland-Jones B, et al. Maintaining normal hemoglobin levels with epoetin alfa in mainly...beneficial effects of maintaining normal hemoglobin levels with the use of recombinant...
- Low or high hemoglobin linked to more heart failure deaths.(Cardiovascular...
- Magazine article from: Internal Medicine News December 15, 2005 700+ words
...15). The low-hemoglobin group had an increased...compared with the normal hemoglobin group. One-year survival...patients in the low-hemoglobin group (OR 1.46...with those with normal hemoglobin. Patients with...
- Normalizing hemoglobin aids hemodialysis patients.
- Newspaper article from: Drug Week July 9, 2004 700+ words
...patients were randomized into a normal hemoglobin group (n=17, target hemoglobin...reactivity was seen in the normal hemoglobin group (p=0.003)," reported...anergy decreased in the normal hemoglobin group (from 60 to 20%) but...
- New findings from University of the West Indies describe advances in sickle...
- Newspaper article from: Blood Weekly November 19, 2009 700+ words
...age 1:1 with 174 mothers with normal hemoglobin phenotype." "Cesarean delivery...sickle cell and in 41 women with normal hemoglobin (24%) left 112 sickle cell and 133 normal hemoglobin pregnancies with spontaneous deliveries...
- Anemia treatment improves heart structure and quality of life in kidney disease...
- Newspaper article from: Heart Disease Weekly April 19, 2009 700+ words
...levels of erythropoietin may result in normal hemoglobin levels (greater than 13 g/dl...treated with erythropoietin to reach a normal hemoglobin level compared with patients who...dl. Treating patients to reach a normal hemoglobin level (>13 g/dl) does not...
- Is there increased fertility in adult males with the sickle cell trait?
- Magazine article from: Human Biology Ezeh, Uchechukwu O; Modebe, Onyechi August 1, 1996 700+ words
...agematched group of subjects with normal hemoglobin genotype. The mean serum concentration...cell trait and subjects with the normal hemoglobin genotype were also statistically...trait (HbAS) over those with the normal hemoglobin genotype (HbAA). The major evidence...
