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New findings on drug composition may allow better preservation in heat.
2004 JUL 7 - (NewsRx.com & NewsRx.net) -- A spoonful of sugar may help the medicine go down, but it may take only a thin coating of freeze-dried sugar to keep insulin, vaccines and other heat-sensitive, protein-based drugs working reliably even when stored at room temperature and above.
Widespread availability of stable, room-temperature therapeutic proteins and vaccines would lower the cost and increase the convenience of these drugs, and could dramatically improve distribution in areas of developing nations where refrigeration may be limited.
New measurements taken by National Institute of Standards and Technology (NIST) scientists and published in Biophysical Journal show that rapidly solidified sugars preserve such proteins best when they suppress tiny, molecular motions lasting a nanosecond or less.
NIST scientists Christopher Soles and Marcus Cicerone used instruments at the NIST Center for Neutron Research to help them view nanoscale molecular motions of sugar mixtures that were designed to encase proteins. ...
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